U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    mat2aa methionine adenosyltransferase 2Aa [ Danio rerio (zebrafish) ]

    Gene ID: 323329, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    mat2aaprovided by ZNC
    Official Full Name
    methionine adenosyltransferase 2Aaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2049
    See related
    Ensembl:ENSDARG00000040334 AllianceGenome:ZFIN:ZDB-GENE-030131-2049
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mat2a; fd12a12; wu:fb95e01; wu:fd12a12; si:ch73-340n8.1
    Summary
    Predicted to enable methionine adenosyltransferase activity. Acts upstream of or within cardiac muscle cell development. Predicted to be part of methionine adenosyltransferase complex. Predicted to be active in cytosol. Is expressed in anterior neural tube; epiphysis; heart; optic cup; and somite. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human MAT2A (methionine adenosyltransferase 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See mat2aa in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (7809019..7821687, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (7850319..7862987, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene surfactant protein Ba Neighboring gene lysyl oxidase a Neighboring gene myeloid-specific peroxidase Neighboring gene phosphatidylinositol 4,5-bisphosphate 5-phosphatase A Neighboring gene uncharacterized LOC137490364 Neighboring gene smoothelin a

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. MAT2A mutations predispose individuals to thoracic aortic aneurysms. Guo DC, et al. Am J Hum Genet, 2015 Jan 8. PMID 25557781, Free PMC Article
    2. Embryo Microinjection of Selenomethionine Reduces Hatchability and Modifies Oxidant Responsive Gene Expression in Zebrafish. Thomas JK, et al. Sci Rep, 2016 May 23. PMID 27210033, Free PMC Article
    3. Trapping cardiac recessive mutants via expression-based insertional mutagenesis screening. Ding Y, et al. Circ Res, 2013 Feb 15. PMID 23283723, Free PMC Article
    4. Disruption of the folate pathway in zebrafish causes developmental defects. Lee MS, et al. BMC Dev Biol, 2012 Apr 5. PMID 22480165, Free PMC Article
    5. Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish. Lawir DF, et al. Commun Biol, 2024 Jan 5. PMID 38182651, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine adenosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionine adenosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within S-adenosylmethionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in S-adenosylmethionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within circulatory system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of methionine adenosyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    methionine adenosyltransferase II, alpha a
    NP_001277009.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290080.1 → NP_001277009.1  methionine adenosyltransferase II, alpha a

      See identical proteins and their annotated locations for NP_001277009.1

      Status: VALIDATED

      Source sequence(s)
      CU681843
      UniProtKB/TrEMBL
      F1QYU7, H9MZH3
      Related
      ENSDARP00000105782.2, ENSDART00000121531.3
      Conserved Domains (4) summary
      PTZ00104
      Location:18 → 395
      PTZ00104; S-adenosylmethionine synthase; Provisional
      pfam00438
      Location:18 → 114
      S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain
      pfam02772
      Location:129 → 250
      S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain
      pfam02773
      Location:252 → 388
      S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      7809019..7821687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_212637.1: Suppressed sequence

      Description
      NM_212637.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.