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    ero1a endoplasmic reticulum oxidoreductase 1 alpha [ Danio rerio (zebrafish) ]

    Gene ID: 393321, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ero1aprovided by ZNC
    Official Full Name
    endoplasmic reticulum oxidoreductase 1 alphaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1312
    See related
    Ensembl:ENSDARG00000015228 AllianceGenome:ZFIN:ZDB-GENE-040426-1312
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ero1l; ERO1-L; zgc:63959
    Summary
    Predicted to enable protein-disulfide reductase activity. Predicted to be involved in protein folding in endoplasmic reticulum. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ERO1A (endoplasmic reticulum oxidoreductase 1 alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ero1a in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (15018129..15029620, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (15010286..15021494, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 16 Neighboring gene G protein-coupled receptor 137c Neighboring gene sterile alpha motif domain containing 4A Neighboring gene GTP cyclohydrolase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. High-content screen using zebrafish (Danio rerio) embryos identifies a novel kinase activator and inhibitor. Geldenhuys WJ, et al. Bioorg Med Chem Lett, 2017 May 1. PMID 28320616, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC63959

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-disulfide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiol oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein folding in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ERO1-like protein alpha
    Names
    ERO1-L-alpha
    endoplasmic reticulum oxidoreductase alpha
    endoplasmic reticulum oxidoreductin-1-like protein
    oxidoreductin-1-L-alpha
    NP_956644.2
    XP_068070440.1
    XP_068070441.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200350.2 → NP_956644.2  ERO1-like protein alpha precursor

      Status: VALIDATED

      Source sequence(s)
      CR387921
      UniProtKB/Swiss-Prot
      Q7T3D1
      UniProtKB/TrEMBL
      A0A0H2UJM0, A0A8M1PEC8
      Related
      ENSDARP00000133796.2, ENSDART00000168332.3
      Conserved Domains (1) summary
      pfam04137
      Location:52 → 447
      ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      15018129..15029620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068214339.1 → XP_068070440.1  ERO1-like protein alpha isoform X1

      UniProtKB/Swiss-Prot
      Q7T3D1

    2. XM_068214340.1 → XP_068070441.1  ERO1-like protein alpha isoform X2

      UniProtKB/Swiss-Prot
      Q7T3D1
      Related
      ENSDARP00000098934.3, ENSDART00000109190.4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7T3D1.1 GenPept UniProtKB/Swiss-Prot:Q7T3D1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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