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    gnb1b guanine nucleotide binding protein (G protein), beta polypeptide 1b [ Danio rerio (zebrafish) ]

    Gene ID: 406796, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gnb1bprovided by ZNC
    Official Full Name
    guanine nucleotide binding protein (G protein), beta polypeptide 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2855
    See related
    Ensembl:ENSDARG00000104372 AllianceGenome:ZFIN:ZDB-GENE-040426-2855
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    GNB1x; gnb1l; fb39f01; zgc:55774; wu:fb39f01; wu:fb98e06; wu:fj09d12
    Summary
    Predicted to enable signaling receptor complex adaptor activity. Acts upstream of or within positive regulation of neutrophil migration and posterior lateral line neuromast primordium migration. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in blastomere; female organism; head; and lateral line system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; autosomal dominant intellectual developmental disorder 42; congestive heart failure; and myelodysplastic syndrome. Orthologous to human GNB1 (G protein subunit beta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See gnb1b in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (53304977..53334159, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (53304598..53333815, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 5 Neighboring gene cysteinyl leukotriene receptor 3 Neighboring gene si:ch211-161c3.5 Neighboring gene si:ch211-161c3.6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Gβ1 is required for neutrophil migration in zebrafish. Ke W, et al. Dev Biol, 2017 Aug 1. PMID 28554852, Free PMC Article
    2. Characterization of zebrafish Esrom (Myc-binding protein 2) RCC1-like domain splice variants. Wang H. Mol Cell Biochem, 2010 Jun. PMID 20143133
    3. Knockout of RP2 decreases GRK1 and rod transducin subunits and leads to photoreceptor degeneration in zebrafish. Liu F, et al. Hum Mol Genet, 2015 Aug 15. PMID 26034134
    4. Gβ1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium. Xu H, et al. Dev Biol, 2014 Jan 15. PMID 24201188, Free PMC Article
    5. Transducin duplicates in the zebrafish retina and pineal complex: differential specialisation after the teleost tetraploidisation. Lagman D, et al. PLoS One, 2015. PMID 25806532, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor complex adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of neutrophil migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within posterior lateral line neuromast primordium migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide binding protein (G protein), beta polypeptide 1b
    Names
    guanine nucleotide binding protein (G protein), beta polypeptide 1, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213481.1 → NP_998646.1  guanine nucleotide binding protein (G protein), beta polypeptide 1b

      See identical proteins and their annotated locations for NP_998646.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044482
      UniProtKB/TrEMBL
      A7YYJ4, Q803H5
      Related
      ENSDARP00000133655.1, ENSDART00000172465.2
      Conserved Domains (2) summary
      cd00200
      Location:48 → 340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:58 → 95
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      53304977..53334159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009302713.3 → XP_009300988.1  guanine nucleotide binding protein (G protein), beta polypeptide 1b isoform X1

      See identical proteins and their annotated locations for XP_009300988.1

      UniProtKB/TrEMBL
      A7YYJ4, Q803H5
      Conserved Domains (2) summary
      cd00200
      Location:48 → 340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:58 → 95
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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