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    sec61a1b SEC61 translocon subunit alpha 1b [ Danio rerio (zebrafish) ]

    Gene ID: 266796, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sec61a1bprovided by ZNC
    Official Full Name
    SEC61 translocon subunit alpha 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-021016-2
    See related
    Ensembl:ENSDARG00000005675 AllianceGenome:ZFIN:ZDB-GENE-021016-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb413; sec61b; sec61a1l; sec61al2; wu:fb36f05; wu:fb36f12; wu:fb37d04; wu:fi26f11
    Summary
    Predicted to enable protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Acts upstream of or within pronephros development. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of Sec61 translocon complex. Is expressed in several structures, including EVL; anterior axial hypoblast; axis; ectoderm; and mesoderm. Human ortholog(s) of this gene implicated in common variable immunodeficiency; familial juvenile hyperuricemic nephropathy; and severe congenital neutropenia. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sec61a1b in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (42377911..42388579, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (42380375..42391043, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 4 (proto-oncogene) Neighboring gene ER membrane protein complex subunit 3 Neighboring gene inositol hexakisphosphate kinase 2a Neighboring gene macrophage stimulating 1 receptor a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Heterozygous Loss-of-Function SEC61A1 Mutations Cause Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney Disease with Anemia. Bolar NA, et al. Am J Hum Genet, 2016 Jul 7. PMID 27392076, Free PMC Article
    2. XBP-1, a key regulator of unfolded protein response, activates transcription of IGF1 and Akt phosphorylation in zebrafish embryonic cell line. Hu MC, et al. Biochem Biophys Res Commun, 2007 Aug 3. PMID 17560942
    3. The Fanconi anemia gene network is conserved from zebrafish to human. Titus TA, et al. Gene, 2006 Apr 26. PMID 16515849
    4. Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition. Du Z, et al. Biochem Biophys Res Commun, 2016 Jun 24. PMID 27235108
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signal sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-translational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pronephros development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Sec61 translocon complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein transport protein Sec61 subunit alpha-like 2
    Names
    SEC61 translocon alpha 1 subunit, like
    SEC61 translocon subunit alpha 1, like
    SEC61, beta subunit
    Sec61 alpha like 2
    transport protein Sec61 subunit alpha like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201577.1 → NP_963871.1  protein transport protein Sec61 subunit alpha-like 2

      See identical proteins and their annotated locations for NP_963871.1

      Status: PROVISIONAL

      Source sequence(s)
      AY034614
      UniProtKB/Swiss-Prot
      Q7ZUL2, Q90YL4
      UniProtKB/TrEMBL
      A0A0J9YIG5
      Related
      ENSDARP00000049424.6, ENSDART00000049425.7
      Conserved Domains (3) summary
      PTZ00219
      Location:1 → 471
      PTZ00219; Sec61 alpha subunit; Provisional
      pfam00344
      Location:75 → 458
      SecY; SecY translocase
      pfam10559
      Location:40 → 73
      Plug_translocon; Plug domain of Sec61p

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      42377911..42388579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q90YL4.3 GenPept UniProtKB/Swiss-Prot:Q90YL4

    Gene LinkOut

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