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    drg1 developmentally regulated GTP binding protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 336823, updated on 9-Dec-2024

    Summary

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    Official Symbol
    drg1provided by ZNC
    Official Full Name
    developmentally regulated GTP binding protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8767
    See related
    Ensembl:ENSDARG00000039345 AllianceGenome:ZFIN:ZDB-GENE-030131-8767
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:64124; wu:fb06g12
    Summary
    Predicted to enable GTP binding activity. Predicted to be involved in cytoplasmic translation. Predicted to be active in cytoplasm. Orthologous to human DRG1 (developmentally regulated GTP binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See drg1 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (17681150..17691171)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (17723716..17733737)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene SNF2 related chromatin remodeling ATPase with DExD box 1b Neighboring gene uncharacterized LOC103911737 Neighboring gene potassium calcium-activated channel subfamily N member 2 Neighboring gene microRNA 218b Neighboring gene StAR related lipid transfer domain containing 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression of two closely related GTP-binding proteins from zebrafish. Wei D, et al. DNA Seq, 2004 Aug. PMID 15620211
    2. Toxicological assessment of trace β-diketone antibiotic mixtures on zebrafish (Danio rerio) by proteomic analysis. Yin X, et al. PLoS One, 2014. PMID 25062015, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    developmentally-regulated GTP-binding protein 1
    NP_956332.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200038.1 → NP_956332.1  developmentally-regulated GTP-binding protein 1

      See identical proteins and their annotated locations for NP_956332.1

      Status: PROVISIONAL

      Source sequence(s)
      BC053264
      UniProtKB/TrEMBL
      A0A8M1PGD4, Q7T340
      Related
      ENSDARP00000057499.5, ENSDART00000057500.6
      Conserved Domains (3) summary
      cd01666
      Location:290 → 365
      TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...
      cd01896
      Location:64 → 296
      DRG; Developmentally Regulated GTP-binding protein (DRG)
      COG1163
      Location:1 → 366
      Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      17681150..17691171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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