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    aplp2 amyloid beta (A4) precursor-like protein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 796801, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aplp2provided by ZNC
    Official Full Name
    amyloid beta (A4) precursor-like protein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061009-28
    See related
    Ensembl:ENSDARG00000054864 AllianceGenome:ZFIN:ZDB-GENE-061009-28
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fk52a05; wu:fk52a05; si:dkey-11k4.3
    Summary
    Predicted to enable heparin binding activity; serine-type endopeptidase inhibitor activity; and transition metal ion binding activity. Predicted to be involved in axonogenesis and central nervous system development. Predicted to be located in endomembrane system and membrane. Is expressed in several structures, including heart; liver; nervous system; pleuroperitoneal region; and solid lens vesicle. Orthologous to human APLP2 (amyloid beta precursor like protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See aplp2 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (44364530..44526895, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (44371076..44533516, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene si:ch211-151h10.2 Neighboring gene PR domain containing 10 Neighboring gene ST14 transmembrane serine protease matriptase a Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 34

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Amyloid precursor protein-b facilitates cell adhesion during early development in zebrafish. Banote RK, et al. Sci Rep, 2020 Jun 23. PMID 32576936, Free PMC Article
    2. Developmental origins of neurotransmitter and transcriptome alterations in adult female zebrafish exposed to atrazine during embryogenesis. Wirbisky SE, et al. Toxicology, 2015 Jul 3. PMID 25929836, Free PMC Article
    3. Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins. Liao HK, et al. Dev Dyn, 2012 Feb. PMID 22275008, Free PMC Article
    4. Members of the vertebrate contactin and amyloid precursor protein families interact through a conserved interface. Karuppan SJ, et al. J Biol Chem, 2022 Feb. PMID 34958801, Free PMC Article
    5. Zebrafish mbnl mutants model physical and molecular phenotypes of myotonic dystrophy. Hinman MN, et al. Dis Model Mech, 2021 Jun 1. PMID 34125183, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these results indicate the Appa-RFP and Aplp2 fusion proteins are likely secreted from the central nervous system and accumulate in the embryonic veins independent of blood flow.
      Title: Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC158408

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    amyloid beta precursor like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123012.1 → NP_001116484.1  amyloid beta precursor like protein 2 precursor

      See identical proteins and their annotated locations for NP_001116484.1

      Status: PROVISIONAL

      Source sequence(s)
      BC160603
      UniProtKB/TrEMBL
      A2BID8, B1H1H1
      Related
      ENSDARP00000071593.5, ENSDART00000077125.6
      Conserved Domains (6) summary
      smart00006
      Location:31 → 195
      A4_EXTRA; amyloid A4
      pfam00014
      Location:314 → 366
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:38 → 138
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:710 → 760
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:140 → 195
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:371 → 553
      APP_E2; E2 domain of amyloid precursor protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      44364530..44526895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068214839.1 → XP_068070940.1  amyloid beta precursor like protein 2 isoform X5

    2. XM_021467714.2 → XP_021323389.1  amyloid beta precursor like protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8M9PFK9
      Conserved Domains (3) summary
      smart00006
      Location:31 → 195
      A4_EXTRA; amyloid A4
      pfam10515
      Location:666 → 716
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:315 → 497
      APP_E2; E2 domain of amyloid precursor protein

    3. XM_021467713.2 → XP_021323388.1  amyloid beta precursor like protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PA77
      Conserved Domains (4) summary
      smart00006
      Location:31 → 195
      A4_EXTRA; amyloid A4
      pfam00014
      Location:314 → 366
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam10515
      Location:691 → 741
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:371 → 553
      APP_E2; E2 domain of amyloid precursor protein

    4. XM_021467712.2 → XP_021323387.1  amyloid beta precursor like protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9P166
      Conserved Domains (4) summary
      smart00006
      Location:31 → 195
      A4_EXTRA; amyloid A4
      pfam00014
      Location:314 → 366
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam10515
      Location:703 → 753
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:371 → 553
      APP_E2; E2 domain of amyloid precursor protein

    5. XM_005159251.5 → XP_005159308.1  amyloid beta precursor like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Q4V0, A0A8M2B668
      Related
      ENSDARP00000147863.1, ENSDART00000189471.1
      Conserved Domains (6) summary
      smart00006
      Location:31 → 195
      A4_EXTRA; amyloid A4
      pfam00014
      Location:314 → 366
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:38 → 138
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:722 → 772
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:140 → 195
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:371 → 553
      APP_E2; E2 domain of amyloid precursor protein
    Nucleotide Protein
    Heading Accession and Version

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