chd1l chromodomain helicase DNA binding protein 1-like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: chd1lprovided by ZNC
Official Full Name: chromodomain helicase DNA binding protein 1-likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-892
See related: Ensembl:ENSDARG00000015471 AllianceGenome:ZFIN:ZDB-GENE-040426-892
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:56084
Summary: Predicted to enable several functions, including ATP hydrolysis activity; histone reader activity; and poly-ADP-D-ribose modification-dependent protein binding activity. Predicted to be involved in DNA damage response and chromatin remodeling. Predicted to act upstream of or within DNA repair. Predicted to be located in chromosome. Predicted to be active in nucleus and site of double-strand break. Orthologous to human CHD1L (chromodomain helicase DNA binding protein 1 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (36844147..36877587)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (36866311..36899693)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP-dependent chromatin remodeler activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent chromatin remodeler activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables histone reader activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	ISS Inferred from Sequence or Structural Similarity more info
enables poly-ADP-D-ribose modification-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: chromodomain-helicase-DNA-binding protein 1-like

NP_956607.1

EC 3.6.4.12

XP_068077768.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200313.1 → NP_956607.1 chromodomain-helicase-DNA-binding protein 1-like

See identical proteins and their annotated locations for NP_956607.1

Status: PROVISIONAL

Source sequence(s)

BC050498

UniProtKB/Swiss-Prot

Q7ZU90

Related

ENSDARP00000022305.6, ENSDART00000020505.8

Conserved Domains (5) summary

cd00046
Location:54 → 194

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

cd03331
Location:709 → 859

Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...

pfam00176
Location:38 → 317

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:335 → 448

Helicase_C; Helicase conserved C-terminal domain

cl00038
Location:951 → 1014

BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...