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    fem1b fem-1 homolog b [ Danio rerio (zebrafish) ]

    Gene ID: 567119, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fem1bprovided by ZNC
    Official Full Name
    fem-1 homolog bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-071009-3
    See related
    Ensembl:ENSDARG00000062636 AllianceGenome:ZFIN:ZDB-GENE-071009-3
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human FEM1B (fem-1 homolog B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See fem1b in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (1335619..1340562)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (1254968..1259917)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene calmodulin-like 4b Neighboring gene coronin, actin binding protein, 2Bb Neighboring gene relaxin family peptide receptor 3.3b Neighboring gene CLN6 transmembrane ER protein b Neighboring gene integrin, alpha 11b Neighboring gene uncharacterized LOC137489309 Neighboring gene serine/threonine-protein kinase WNK3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein fem-1 homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      1335619..1340562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_690410.9 → XP_695502.4  protein fem-1 homolog B

      UniProtKB/TrEMBL
      A0A8N7T7R8, E7F7Y4
      Related
      ENSDARP00000085236.4, ENSDART00000090803.6
      Conserved Domains (4) summary
      COG0666
      Location:500 → 589
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:98 → 218
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:103 → 194
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:98 → 129
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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