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    NHX4 sodium hydrogen exchanger 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819811, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NHX4
    Official Full Name
    sodium hydrogen exchanger 4
    Primary source
    TAIR:AT3G06370
    Locus tag
    AT3G06370
    See related
    Araport:AT3G06370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATNHX4; F24P17.16; F24P17_16; sodium hydrogen exchanger 4
    Summary
    member of Sodium proton exchanger family
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    Genomic context

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    See NHX4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Sequence:
    Chromosome: 3; NC_003074.8 (1929946..1934073, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene dehydroquinate dehydratase, putative / shikimate dehydrogenase Neighboring gene arabinogalactan protein 27 Neighboring gene tubby-like protein 9 Neighboring gene Uncharacterized protein family (UPF0497)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Knock-out of Arabidopsis AtNHX4 gene enhances tolerance to salt stress. Li HT, et al. Biochem Biophys Res Commun, 2009 May 8. PMID 19306843
    2. Cation Specificity of Vacuolar NHX-Type Cation/H(+) Antiporters. Bassil E, et al. Plant Physiol, 2019 Feb. PMID 30498025, Free PMC Article
    3. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article
    4. A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture. Jaquinod M, et al. Mol Cell Proteomics, 2007 Mar. PMID 17151019, Free PMC Article
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001337652.1
    NM_111512.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables sodium ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sodium:proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of pH IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sodium hydrogen exchanger 4
    NP_187288.2
    • sodium hydrogen exchanger 4 (NHX4); FUNCTIONS IN: sodium:hydrogen antiporter activity, sodium ion transmembrane transporter activity; INVOLVED IN: response to salt stress, sodium ion transport; LOCATED IN: vacuolar membrane, plasma membrane; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Na+/H+ exchanger, subfamily (InterPro:IPR004709), Cation/H+ exchanger, conserved region (InterPro:IPR018422), Cation/H+ exchanger (InterPro:IPR006153), Na+/H+ exchanger, isoforms 1-4, conserved region (InterPro:IPR018407); BEST Arabidopsis thaliana protein match is: sodium hydrogen exchanger 2 (TAIR:AT3G05030.1); Has 5892 Blast hits to 5885 proteins in 1663 species: Archae - 61; Bacteria - 4002; Metazoa - 840; Fungi - 131; Plants - 419; Viruses - 0; Other Eukaryotes - 439 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1929946..1934073 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001337651.1 → NP_001327379.1  sodium hydrogen exchanger 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VAM2, A0A1I9LS48, A0A384KPV5, A0A7G2EG13
      Conserved Domains (1) summary
      TIGR00840
      Location:46 → 470
      b_cpa1; sodium/hydrogen exchanger 3

    2. NM_001337650.1 → NP_001327378.1  sodium hydrogen exchanger 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LS49

    3. NM_111512.3 → NP_187288.2  sodium hydrogen exchanger 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187288.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84WG1, Q9SQU0
      UniProtKB/TrEMBL
      A0A7G2EG13
      Conserved Domains (1) summary
      COG0025
      Location:52 → 462
      NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]

    4. NM_001337652.1 → NP_001327377.1  sodium hydrogen exchanger 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VAM2, A0A1I9LS48, A0A384KPV5, A0A7G2EG13
      Conserved Domains (1) summary
      TIGR00840
      Location:46 → 470
      b_cpa1; sodium/hydrogen exchanger 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84WG1.2

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