myhz1.3 myosin, heavy polypeptide 1.3, skeletal muscle [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: myhz1.3provided by ZNC
Official Full Name: myosin, heavy polypeptide 1.3, skeletal muscleprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070705-74
See related: Ensembl:ENSDARG00000067997 AllianceGenome:ZFIN:ZDB-GENE-070705-74
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: myhz1; fmyhcx; fmyhc1.3; ns:zf-e68; si:ch211-158m24.9
Summary: Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in system development. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in adaxial cell; fast muscle cell; and trunk. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; contractures, pterygia, and spondylocarpotarsal fusion syndrome (multiple); disease of cellular proliferation; and distal arthrogryposis (multiple). Orthologous to several human genes including MYH1 (myosin heavy chain 1); MYH4 (myosin heavy chain 4); and MYH8 (myosin heavy chain 8). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 5

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (32262499..32274382, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (31662346..31674233, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI437080 (e-PCR)
- UniSTS:206592

fi38g05.x1 (e-PCR)
- UniSTS:197430

fi17f08.x1 (e-PCR)
- UniSTS:196933

fb26f12 (e-PCR)
- UniSTS:189003

h56846 (e-PCR)
- UniSTS:186965

AI617435 (e-PCR)
- UniSTS:206169

fd14a01.x1 (e-PCR)
- UniSTS:204157

fb54g09.y1 (e-PCR)
- UniSTS:190714

aa566396 (e-PCR)
- UniSTS:186878

aa566432 (e-PCR)
- UniSTS:186879

Homology

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myosin heavy chain, fast skeletal muscle

Names: fast skeletal muscle myosin heavy polypeptide 1; myosin, heavy polypeptide 2, fast muscle

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

32262499..32274382 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001923979.8 → XP_001924014.2 myosin heavy chain, fast skeletal muscle

UniProtKB/TrEMBL

A0A8M1QRD9, B8A569, E7F1Z4

Related

ENSDARP00000111326.2, ENSDART00000122889.3

Conserved Domains (7) summary

cd01377
Location:101 → 768

MYSc_class_II; class II myosins, motor domain

pfam00063
Location:89 → 768

Myosin_head; Myosin head (motor domain)

pfam01576
Location:882 → 1925

Myosin_tail_1; Myosin tail

pfam02736
Location:36 → 74

Myosin_N; Myosin N-terminal SH3-like domain

pfam07851
Location:1473 → 1583

TMPIT; TMPIT-like protein

cl00459
Location:1297 → 1409

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl02488
Location:881 → 1043

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...