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    stk25a serine/threonine kinase 25a [ Danio rerio (zebrafish) ]

    Gene ID: 449653, updated on 4-Jan-2025

    Summary

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    Official Symbol
    stk25aprovided by ZNC
    Official Full Name
    serine/threonine kinase 25aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-92
    See related
    Ensembl:ENSDARG00000002210 AllianceGenome:ZFIN:ZDB-GENE-041010-92
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92836
    Summary
    Predicted to enable ATP binding activity; metal ion binding activity; and protein serine/threonine kinase activity. Acts upstream of or within axis elongation and heart development. Predicted to be located in cytoplasm. Is expressed in cranial ganglion and pharyngeal arch. Orthologous to human STK25 (serine/threonine kinase 25). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See stk25a in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (27041595..27057722, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (27051033..27067148, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene ephexin-1 Neighboring gene FERM, RhoGEF and pleckstrin domain protein 2 Neighboring gene BCL2 family apoptosis regulator BOK a Neighboring gene autophagy related 4B, cysteine peptidase Neighboring gene deoxythymidylate kinase (thymidylate kinase)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease. Yoruk B, et al. Dev Biol, 2012 Feb 15. PMID 22182521
    2. CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations. Zheng X, et al. J Clin Invest, 2010 Aug. PMID 20592472, Free PMC Article
    3. Unraveling Differential Transcriptomes and Cell Types in Zebrafish Larvae Intestine and Liver. Gao Y, et al. Cells, 2022 Oct 19. PMID 36291156, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axis elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 25a
    Names
    stk25b
    NP_001306985.1
    XP_005165982.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320056.1 → NP_001306985.1  serine/threonine-protein kinase 25a

      Status: VALIDATED

      Source sequence(s)
      CU467043, EH435265, EH524747
      UniProtKB/TrEMBL
      A0A8M1P2C4, F8W562
      Related
      ENSDARP00000123777.1, ENSDART00000149363.2
      Conserved Domains (2) summary
      smart00220
      Location:20 → 270
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06609
      Location:20 → 291
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      27041595..27057722 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165925.5 → XP_005165982.1  serine/threonine-protein kinase 25a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BDG3
      Conserved Domains (2) summary
      smart00220
      Location:20 → 270
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06609
      Location:20 → 291
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001005925.1: Suppressed sequence

      Description
      NM_001005925.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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