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    golgb1 golgin B1 [ Danio rerio (zebrafish) ]

    Gene ID: 566353, updated on 9-Dec-2024

    Summary

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    Official Symbol
    golgb1provided by ZNC
    Official Full Name
    golgin B1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030429-9
    See related
    Ensembl:ENSDARG00000061951 AllianceGenome:ZFIN:ZDB-GENE-030429-9
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    giantin; sb:cb277; wu:fb47h05; wu:fb92f11
    Summary
    Predicted to be located in Golgi apparatus and membrane. Predicted to be active in cis-Golgi network and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in axis; floor plate; hypochord; otic placode; and polster. Used to study hyperphosphatemic familial tumoral calcinosis. Orthologous to human GOLGB1 (golgin B1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See golgb1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (22312990..22338944, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (22592015..22617959, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137491548 Neighboring gene LLP homolog, long-term synaptic facilitation factor Neighboring gene hematopoietic cell-specific Lyn substrate 1 Neighboring gene uncharacterized LOC101884046 Neighboring gene uncharacterized LOC137491547 Neighboring gene guanylate cyclase activator 1Aa Neighboring gene origin recognition complex, subunit 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Giantin is required for intracellular N-terminal processing of type I procollagen. Stevenson NL, et al. J Cell Biol, 2021 Jun 7. PMID 33944912, Free PMC Article
    2. Giantin-knockout models reveal a feedback loop between Golgi function and glycosyltransferase expression. Stevenson NL, et al. J Cell Sci, 2017 Dec 15. PMID 29093022, Free PMC Article
    3. Novel zebrafish caspase-3 substrates. Valencia CA, et al. Biochem Biophys Res Commun, 2007 Sep 21. PMID 17643392
    4. The Golgi matrix protein giantin is required for normal cilia function in zebrafish. Bergen DJM, et al. Biol Open, 2017 Aug 15. PMID 28546340, Free PMC Article
    5. A comparative map of the zebrafish genome. Woods IG, et al. Genome Res, 2000 Dec. PMID 11116086, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Golgin subfamily B member 1; golgin subfamily B member 1
    Names
    golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      22312990..22338944 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068220776.1 → XP_068076877.1  golgin subfamily B member 1 isoform X2

      Related
      ENSDARP00000122063.2, ENSDART00000131402.3

    2. XM_005164908.5 → XP_005164965.1  golgin subfamily B member 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BC86
      Conserved Domains (3) summary
      TIGR02168
      Location:1229 → 2039
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam11898
      Location:2432 → 2566
      DUF3418; Domain of unknown function (DUF3418)
      pfam15350
      Location:1795 → 1881
      ETAA1; Ewing's tumour-associated antigen 1 homologue

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001045103.1: Suppressed sequence

      Description
      NM_001045103.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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