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    rgs12a regulator of G protein signaling 12a [ Danio rerio (zebrafish) ]

    Gene ID: 570516, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rgs12aprovided by ZNC
    Official Full Name
    regulator of G protein signaling 12aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2614
    See related
    Ensembl:ENSDARG00000009610 AllianceGenome:ZFIN:ZDB-GENE-030131-2614
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc13d03; wu:fc13d03
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Orthologous to human RGS12 (regulator of G protein signaling 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rgs12a in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (18474558..18547430, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (18222291..18295168, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene somatostatin receptor 1b Neighboring gene zinc finger protein 16 like Neighboring gene Myb/SANT-like DNA-binding domain containing 1 Neighboring gene deltex 4, E3 ubiquitin ligase a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    regulator of G-protein signaling 12; uncharacterized protein LOC570516

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      18474558..18547430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009303086.4 → XP_009301361.1  regulator of G-protein signaling 12 isoform X3

      UniProtKB/TrEMBL
      A0A8M3B3Z7
      Conserved Domains (7) summary
      cd08706
      Location:682 → 796
      RGS_R12-like; Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins
      cd00992
      Location:12 → 87
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:223 → 353
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      pfam02188
      Location:1138 → 1159
      GoLoco; GoLoco motif
      pfam16612
      Location:1174 → 1283
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:802 → 891
      RGS12_us1; Unstructured region of RGS12
      cl00155
      Location:935 → 1006
      UBQ; Ubiquitin-like proteins

    2. XM_009303085.4 → XP_009301360.1  regulator of G-protein signaling 12 isoform X2

      UniProtKB/TrEMBL
      A0A1D5NS62, A0A8M3AU18, F1QV08
      Related
      ENSDARP00000142671.1, ENSDART00000173969.2
      Conserved Domains (7) summary
      cd08706
      Location:682 → 796
      RGS_R12-like; Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins
      cd00992
      Location:12 → 87
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:223 → 353
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      pfam02188
      Location:1138 → 1159
      GoLoco; GoLoco motif
      pfam16612
      Location:1174 → 1283
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:802 → 891
      RGS12_us1; Unstructured region of RGS12
      cl00155
      Location:936 → 1007
      UBQ; Ubiquitin-like proteins

    3. XM_694005.9 → XP_699097.4  regulator of G-protein signaling 12 isoform X1

      UniProtKB/TrEMBL
      A0A8N7URF2
      Conserved Domains (7) summary
      cd08706
      Location:682 → 796
      RGS_R12-like; Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins
      cd00992
      Location:12 → 87
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:223 → 353
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      pfam02188
      Location:1139 → 1160
      GoLoco; GoLoco motif
      pfam16612
      Location:1175 → 1284
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:802 → 891
      RGS12_us1; Unstructured region of RGS12
      cl00155
      Location:936 → 1007
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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