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    pum1 pumilio RNA-binding family member 1 [ Danio rerio (zebrafish) ]

    Gene ID: 394176, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pum1provided by ZNC
    Official Full Name
    pumilio RNA-binding family member 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2074
    See related
    Ensembl:ENSDARG00000099256 AllianceGenome:ZFIN:ZDB-GENE-030131-2074
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb96a03; pumilio1; zgc:63671; wu:fb96a03; wu:fb96a08; si:ch211-285e16.1
    Summary
    Enables mRNA binding activity. Involved in pole plasm mRNA localization. Predicted to be active in cytosol. Is expressed in oocyte stage IV and ovary. Human ortholog(s) of this gene implicated in cerebellar ataxia type 47. Orthologous to human PUM1 (pumilio RNA binding family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pum1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (43037657..43089455)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (43468220..43517760)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein 40 (U5) Neighboring gene sodium/potassium transporting ATPase interacting 1 Neighboring gene small nucleolar RNA SNORA5 Neighboring gene small nucleolar RNA SNORA5 Neighboring gene eukaryotic translation elongation factor 1 alpha 1, like 1 Neighboring gene eukaryotic translation elongation factor 1 alpha 1, like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Changes in subcellular structures and states of pumilio 1 regulate the translation of target Mad2 and cyclin B1 mRNAs. Takei N, et al. J Cell Sci, 2020 Dec 11. PMID 33148609
    2. Pumilio1 phosphorylation precedes translational activation of its target mRNA in zebrafish oocytes. Saitoh A, et al. Zygote, 2018 Oct. PMID 30289101
    3. Staufen1, Kinesin1 and microtubule function in cyclin B1 mRNA transport to the animal polar cytoplasm of zebrafish oocytes. Takahashi K, et al. Biochem Biophys Res Commun, 2018 Sep 18. PMID 30103945
    4. Cyclin B1 mRNA translation is temporally controlled through formation and disassembly of RNA granules. Kotani T, et al. J Cell Biol, 2013 Sep 30. PMID 24062337, Free PMC Article
    5. Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo. Lemeer S, et al. J Proteome Res, 2008 Apr. PMID 18307296

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63671

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pole plasm mRNA localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pumilio homolog 1
    Names
    pumilio homolog 1 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277119.2 → NP_001264048.1  pumilio homolog 1

      Status: VALIDATED

      Source sequence(s)
      AB841266, BC055197
      UniProtKB/TrEMBL
      A0A0R4IWL6, A0A8M1NZX5, S6B5C2
      Related
      ENSDARP00000140793.2, ENSDART00000168263.2
      Conserved Domains (1) summary
      cd07920
      Location:807 → 1130
      Pumilio; Pumilio-family RNA binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      43037657..43089455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_201201.1: Suppressed sequence

      Description
      NM_201201.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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