ubiad1 UbiA prenyltransferase domain containing 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ubiad1provided by ZNC
Official Full Name: UbiA prenyltransferase domain containing 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3205
See related: Ensembl:ENSDARG00000013009 AllianceGenome:ZFIN:ZDB-GENE-030131-3205
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fc30e12
Summary: Enables antioxidant activity; nitric-oxide synthase activity; and prenyltransferase activity. Involved in several processes, including endothelial cell development; menaquinone biosynthetic process; and vitamin K biosynthetic process. Acts upstream of or within cellular response to fluid shear stress and ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate. Located in Golgi membrane. Is expressed in head; heart; and heart tube. Human ortholog(s) of this gene implicated in Schnyder corneal dystrophy. Orthologous to human UBIAD1 (UbiA prenyltransferase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (53918234..53926228, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (53587152..53593948, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study identified a gene with important antioxidant features by analyzing a null allele of zebrafish ubiad1, called barolo (bar). bar mutants show specific cardiovascular failure due to oxidative stress and reactive oxygen species-mediated cellular damage.
Title: Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis.

Submit: New GeneRIF Correction

General gene information

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Markers

z99331 (e-PCR), detects polymorphism
- UniSTS:238623

fc30e12.x1 (e-PCR)
- UniSTS:187940

z99330 (e-PCR), detects polymorphism
- UniSTS:238585

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 4-hydroxybenzoate polyprenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables antioxidant activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables nitric-oxide synthase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables prenyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prenyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables prenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables prenyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring alkyl or aryl (other than methyl) groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to fluid shear stress	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within circulatory system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circulatory system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in menaquinone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within menaquinone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in menaquinone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in menaquinone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ubiquinone biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquinone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquinone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vitamin K biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in vitamin K biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiA prenyltransferase domain-containing protein 1

Names: bar; barolo; protein barolo; protein reddish; unm t31131; unm_t31131

NP_001186655.1

EC 2.5.1.39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.