eif3c eukaryotic translation initiation factor 3, subunit C [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: eif3cprovided by ZNC
Official Full Name: eukaryotic translation initiation factor 3, subunit Cprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6166
See related: Ensembl:ENSDARG00000016443 AllianceGenome:ZFIN:ZDB-GENE-030131-6166
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: eif3s8; fi37c04; zgc:66128; wu:fb34a08; wu:fi37c04
Summary: Predicted to enable translation initiation factor binding activity. Predicted to contribute to translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to act upstream of or within translation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex. Orthologous to several human genes including EIF3C (eukaryotic translation initiation factor 3 subunit C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (3944229..3962374, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (3907464..3925627, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

fi37c04.x1 (e-PCR)
- UniSTS:197402

AI436870 (e-PCR)
- UniSTS:206618

fb34a08.x1 (e-PCR)
- UniSTS:203130

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
contributes_to translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
contributes_to translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables translation initiation factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in formation of cytoplasmic translation initiation complex	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within translational initiation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 43S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 3 complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 3 subunit C

Names: eukaryotic translation initiation factor 3, subunit 8, 110kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213463.1 → NP_998628.1 eukaryotic translation initiation factor 3 subunit C

See identical proteins and their annotated locations for NP_998628.1

Status: PROVISIONAL

Source sequence(s)

BC057465

UniProtKB/Swiss-Prot

Q6PFQ2

Related

ENSDARP00000011344.9, ENSDART00000016791.11

Conserved Domains (2) summary

smart00753
Location:777 → 862

PAM; PCI/PINT associated module

pfam05470
Location:31 → 704

eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

3944229..3962374 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005155999.5 → XP_005156056.1 eukaryotic translation initiation factor 3 subunit C isoform X1

UniProtKB/TrEMBL

A0A8M2B2W0

Conserved Domains (3) summary

smart00753
Location:777 → 862

PAM; PCI/PINT associated module

pfam05091
Location:888 → 939

eIF-3_zeta; Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)

pfam05470
Location:31 → 704

eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus