U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    thy1 Thy-1 cell surface antigen [ Danio rerio (zebrafish) ]

    Gene ID: 336617, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    thy1provided by ZNC
    Official Full Name
    Thy-1 cell surface antigenprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8561
    See related
    Ensembl:ENSDARG00000035018 AllianceGenome:ZFIN:ZDB-GENE-030131-8561
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb15c03; wu:fb18g05; zgc:123140
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in integrin-mediated signaling pathway and positive regulation of focal adhesion assembly. Predicted to act upstream of or within cell adhesion and regulation of cell migration. Predicted to be located in plasma membrane. Predicted to be active in dendrite; external side of plasma membrane; and membrane raft. Is expressed in eye. Orthologous to human THY1 (Thy-1 cell surface antigen). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See thy1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (29794040..29803293)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (29193887..29203140)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene BarH-like homeobox 1a Neighboring gene cilia and flagella associated protein 77 Neighboring gene si:ch211-215c18.3 Neighboring gene upstream transcription factor 1, like Neighboring gene F11 receptor, tandem duplicate 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of teleost Thy-1 and association with the microdomain/lipid raft reggie proteins in regenerating CNS axons. Deininger SO, et al. Mol Cell Neurosci, 2003 Apr. PMID 12727449
    2. Spatiotemporal mapping of gene expression landscapes and developmental trajectories during zebrafish embryogenesis. Liu C, et al. Dev Cell, 2022 May 23. PMID 35512701
    3. Evolutionary analysis and expression of teleost Thy-1. Reuter A, et al. Zebrafish, 2004. PMID 18248231
    4. Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig. Liu J, et al. Nat Commun, 2016 Oct 7. PMID 27713410, Free PMC Article
    5. Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma. Veth KN, et al. PLoS Genet, 2011 Feb. PMID 21379331, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC123140

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA-DNA hybrid ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    thy-1 membrane glycoprotein
    NP_001300699.1
    XP_021331692.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313770.1 → NP_001300699.1  thy-1 membrane glycoprotein precursor

      Status: VALIDATED

      Source sequence(s)
      EH526245, EH546814, EH577813
      UniProtKB/TrEMBL
      A0A8M1P731, A2BFD8
      Related
      ENSDARP00000045409.6, ENSDART00000045410.7

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      29794040..29803293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476017.2 → XP_021331692.2  thy-1 membrane glycoprotein isoform X1

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394581.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      153342..155207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395239.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      151074..160327
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198065.1: Suppressed sequence

      Description
      NM_198065.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools