U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    dgkaa diacylglycerol kinase, alpha a [ Danio rerio (zebrafish) ]

    Gene ID: 724010, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    dgkaaprovided by ZNC
    Official Full Name
    diacylglycerol kinase, alpha aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060616-305
    See related
    Ensembl:ENSDARG00000060626 AllianceGenome:ZFIN:ZDB-GENE-060616-305
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dgka; zgc:136759
    Summary
    Predicted to enable ATP-dependent diacylglycerol kinase activity. Predicted to be involved in diacylglycerol metabolic process; intracellular signal transduction; and phosphatidic acid biosynthetic process. Predicted to act upstream of or within lipid metabolic process; phosphorylation; and signal transduction. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Orthologous to human DGKA (diacylglycerol kinase alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See dgkaa in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (32239338..32304697, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (32312807..32378169, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 4, group A, member 1 Neighboring gene uncharacterized LOC103909698 Neighboring gene trafficking regulator and scaffold protein tamalin Neighboring gene ring finger protein 41 Neighboring gene solute carrier family 39 member 5

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of differentially expressed genes in the zebrafish hypothalamic-pituitary axis. Toro S, et al. Gene Expr Patterns, 2009 Apr. PMID 19166982, Free PMC Article
    2. Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. Takeuchi M, et al. J Comp Neurol, 2017 May 1. PMID 27615194
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    diacylglycerol kinase, alpha a
    NP_001038780.1
    XP_005162385.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045315.1 → NP_001038780.1  diacylglycerol kinase, alpha a

      See identical proteins and their annotated locations for NP_001038780.1

      Status: PROVISIONAL

      Source sequence(s)
      BC117645
      UniProtKB/TrEMBL
      A0A8N7UYC6, Q1ECW5
      Related
      ENSDARP00000080077.4, ENSDART00000085642.6
      Conserved Domains (8) summary
      smart00045
      Location:524 → 697
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:382 → 503
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:382 → 705
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00029
      Location:208 → 257
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:117 → 186
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:118 → 182
      EF-hand_7; EF-hand domain pair
      pfam14513
      Location:12 → 112
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cl00040
      Location:273 → 325
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      32239338..32304697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162328.5 → XP_005162385.1  diacylglycerol kinase, alpha a isoform X1

      UniProtKB/TrEMBL
      A0A2R8Q6S0, A0A8M2B985
      Related
      ENSDARP00000146803.1, ENSDART00000188989.1
      Conserved Domains (8) summary
      smart00045
      Location:563 → 736
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:421 → 542
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:421 → 744
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00029
      Location:247 → 296
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:156 → 225
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:157 → 221
      EF-hand_7; EF-hand domain pair
      pfam14513
      Location:12 → 151
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cl00040
      Location:312 → 364
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395161.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      200559..269831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools