adkb adenosine kinase b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adkbprovided by ZNC
Official Full Name: adenosine kinase bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-948
See related: Ensembl:ENSDARG00000095947 AllianceGenome:ZFIN:ZDB-GENE-030131-948
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb980; fb53h03; wu:fb53h03
Summary: Predicted to enable adenosine kinase activity. Predicted to be involved in purine nucleobase metabolic process. Predicted to act upstream of or within phosphorylation and purine ribonucleoside salvage. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alar plate midbrain region; liver; midbrain; musculature system; and segmental plate. Human ortholog(s) of this gene implicated in hypermethioninemia due to adenosine kinase deficiency. Orthologous to human ADK (adenosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (46842395..46868003)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (46826210..46851818)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

AI497460 (e-PCR)
- UniSTS:206342

fb53h03.x1 (e-PCR)
- UniSTS:203315

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenosine kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in AMP salvage	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in purine nucleobase metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within purine ribonucleoside salvage	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adenosine kinase b

NP_942097.1

EC 2.7.1.20

XP_068080622.1

EC 2.7.1.20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198802.1 → NP_942097.1 adenosine kinase b

See identical proteins and their annotated locations for NP_942097.1

Status: PROVISIONAL

Source sequence(s)

BC051621

UniProtKB/TrEMBL

Q7ZTT5

Related

ENSDARP00000134061.1, ENSDART00000157464.3

Conserved Domains (2) summary

PTZ00247
Location:2 → 344

PTZ00247; adenosine kinase; Provisional

cl00192
Location:12 → 344

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...