sec31a SEC31 homolog A, COPII coat complex component [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sec31aprovided by ZNC
Official Full Name: SEC31 homolog A, COPII coat complex componentprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020919-2
See related: Ensembl:ENSDARG00000021082 AllianceGenome:ZFIN:ZDB-GENE-020919-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb354; sec31p; zgc:63547
Summary: Predicted to enable structural molecule activity. Acts upstream of or within digestive system development; endoplasmic reticulum organization; and liver development. Predicted to be located in COPII-coated ER to Golgi transport vesicle. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Is expressed in several structures, including alar plate midbrain region; axis; digestive system; fin; and midbrain. Human ortholog(s) of this gene implicated in Halperin-Birk syndrome. Orthologous to human SEC31A (SEC31 homolog A, COPII coat complex component). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (5092511..5135788, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (5092169..5135484, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

efficient COPII-dependent secretion, notably assembly of Sec13-Sec31, is required to drive epithelial morphogenesis
Title: Epithelial organization and cyst lumen expansion require efficient Sec13-Sec31-driven secretion.
Data show that coupling of Sec23/24 and Sec13/31 layers of the COPII coat is required to drive export of collagen from the endoplasmic reticulum, and that COPII assembly is essential for normal craniofacial development during embryogenesis.
Title: Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables structural molecule activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in COPII-coated vesicle cargo loading	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within digestive system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endoplasmic reticulum organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of COPII vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
part_of COPII vesicle coat	ISS Inferred from Sequence or Structural Similarity more info
located_in COPII-coated ER to Golgi transport vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum exit site	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum exit site	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein transport protein Sec31A

Names: SEC31-like protein 1; SEC31-related protein A; sec31p homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199530.2 → NP_955824.2 protein transport protein Sec31A

Status: VALIDATED

Source sequence(s)

CR847788

UniProtKB/Swiss-Prot

Q7SYD5

UniProtKB/TrEMBL

A0A8M1PE08, F1R5G5

Related

ENSDARP00000104171.2, ENSDART00000108587.4

Conserved Domains (4) summary

COG2319
Location:88 → 407

WD40; WD40 repeat [General function prediction only]

sd00039
Location:13 → 69

7WD40; WD40 repeat [structural motif]

cl02567
Location:86 → 337

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl14807
Location:573 → 770

ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

5092511..5135788 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021479100.2 → XP_021334775.1 protein transport protein Sec31A isoform X7

UniProtKB/TrEMBL

A0A8M9QKI6

Conserved Domains (4) summary

sd00039
Location:13 → 69

7WD40; WD40 repeat [structural motif]

cl14807
Location:881 → 1078

ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

cl25539
Location:86 → 337

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl27975
Location:1152 → 1297

EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
XM_009305092.4 → XP_009303367.1 protein transport protein Sec31A isoform X5

UniProtKB/TrEMBL

A0A8M3AWH9

Conserved Domains (4) summary

COG2319
Location:88 → 407

WD40; WD40 repeat [General function prediction only]

sd00039
Location:13 → 69

7WD40; WD40 repeat [structural motif]

cl02567
Location:86 → 337

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl14807
Location:881 → 1078

ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
XM_009305094.4 → XP_009303369.1 protein transport protein Sec31A isoform X6

UniProtKB/TrEMBL

A0A8M3BCT3

Conserved Domains (4) summary

COG2319
Location:88 → 407

WD40; WD40 repeat [General function prediction only]

sd00039
Location:13 → 69

7WD40; WD40 repeat [structural motif]

cl02567
Location:86 → 337

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl14807
Location:881 → 1078

ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
XM_009305091.4 → XP_009303366.1 protein transport protein Sec31A isoform X4

UniProtKB/TrEMBL

A0A8M3B316

Conserved Domains (4) summary

COG2319
Location:88 → 407

WD40; WD40 repeat [General function prediction only]

sd00039
Location:13 → 69

7WD40; WD40 repeat [structural motif]

cl02567
Location:86 → 337

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl14807
Location:881 → 1078

ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
XM_009305090.4 → XP_009303365.1 protein transport protein Sec31A isoform X3

UniProtKB/Swiss-Prot

Q7SYD5

UniProtKB/TrEMBL

A0A8M3B600

Conserved Domains (4) summary

COG2319
Location:88 → 407

WD40; WD40 repeat [General function prediction only]

sd00039
Location:13 → 69

7WD40; WD40 repeat [structural motif]

cl02567
Location:86 → 337

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl14807
Location:881 → 1078

ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
XM_009305089.4 → XP_009303364.1 protein transport protein Sec31A isoform X2

UniProtKB/Swiss-Prot

Q7SYD5

UniProtKB/TrEMBL

A0A8M3AWG1

Conserved Domains (4) summary

COG2319
Location:88 → 407

WD40; WD40 repeat [General function prediction only]

sd00039
Location:13 → 69

7WD40; WD40 repeat [structural motif]

cl02567
Location:86 → 337

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl14807
Location:881 → 1078

ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
XM_009305088.4 → XP_009303363.1 protein transport protein Sec31A isoform X1

UniProtKB/Swiss-Prot

Q7SYD5

UniProtKB/TrEMBL

A0A8M3BCS9

Conserved Domains (4) summary

COG2319
Location:88 → 407

WD40; WD40 repeat [General function prediction only]

sd00039
Location:13 → 69

7WD40; WD40 repeat [structural motif]

cl02567
Location:86 → 337

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl14807
Location:881 → 1078

ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16