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    PAH1 Lipin family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820113, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PAH1
    Official Full Name
    Lipin family protein
    Primary source
    TAIR:AT3G09560
    Locus tag
    AT3G09560
    See related
    Araport:AT3G09560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPAH1; PHOSPHATIDIC ACID PHOSPHOHYDROLASE 1
    Summary
    The PAH1 gene encodes a phosphatidate phosphohydrolase. Mutant analysis revealed its involvement in galactolipid synthesis pathway, and the membrane lipid remodeling. The pah1pah2 double-mutant showed enhanced Al-susceptibility under low-P conditions, but there was no significant differences in Al tolerance between pah1pah2 and wild type when they were grown in a solution containing 35 muM Pi.
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    Genomic context

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    See PAH1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Sequence:
    Chromosome: 3; NC_003074.8 (2934592..2939511, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene exocyst subunit exo70 family protein H3 Neighboring gene Pectin lyase-like superfamily protein Neighboring gene Ankyrin repeat family protein Neighboring gene Lung seven transmembrane receptor family protein Neighboring gene FAD/NAD(P)-binding oxidoreductase family protein Neighboring gene tRNA-Ser

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The rice RMR1 associates with a distinct prevacuolar compartment for the protein storage vacuole pathway. Shen Y, et al. Mol Plant, 2011 Sep. PMID 21493745
    2. Phosphatidic acid phosphohydrolase 1 and 2 regulate phospholipid synthesis at the endoplasmic reticulum in Arabidopsis. Eastmond PJ, et al. Plant Cell, 2010 Aug. PMID 20699392, Free PMC Article
    3. Arabidopsis lipins mediate eukaryotic pathway of lipid metabolism and cope critically with phosphate starvation. Nakamura Y, et al. Proc Natl Acad Sci U S A, 2009 Dec 8. PMID 19923426, Free PMC Article
    4. Cyclin-dependent kinase activity enhances phosphatidylcholine biosynthesis in Arabidopsis by repressing phosphatidic acid phosphohydrolase activity. Craddock CP, et al. Plant J, 2017 Jan. PMID 27595588, Free PMC Article
    5. Deciphering the roles of Arabidopsis LPCAT and PAH in phosphatidylcholine homeostasis and pathway coordination for chloroplast lipid synthesis. Wang L, et al. Plant J, 2014 Dec. PMID 25268378

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that phosphatidylcholine (PC) biosynthesis is repressed by disruption of the core cell cycle regulator CYCLIN-DEPENDENT KINASE A;1 (CDKA;1) and that this repression is reliant on PHOSPHATIDIC ACID PHOSPHOHYDROLASE (PAH).
      Title: Cyclin-dependent kinase activity enhances phosphatidylcholine biosynthesis in Arabidopsis by repressing phosphatidic acid phosphohydrolase activity.
    2. PAH1 and PAH2 function indirectly as repressors of phospholipid biosynthesis.
      Title: Phosphatidic acid phosphohydrolase 1 and 2 regulate phospholipid synthesis at the endoplasmic reticulum in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001125132.1
    NM_001337827.1
    NM_111790.4
    NM_202539.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphatidate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidate phosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to phosphate starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within galactolipid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular protein transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within phospholipid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in protein storage vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Lipin family protein
    NP_001118604.1
    • Lipin family protein; FUNCTIONS IN: phosphatidate phosphatase activity; INVOLVED IN: cellular response to phosphate starvation, lipid metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: LNS2, Lipin/Ned1/Smp2 (InterPro:IPR013209), Lipin, N-terminal conserved region (InterPro:IPR007651); BEST Arabidopsis thaliana protein match is: phosphatidic acid phosphohydrolase 2 (TAIR:AT5G42870.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_187567.1
    • PHOSPHATIDIC ACID PHOSPHOHYDROLASE 1 (PAH1); CONTAINS InterPro DOMAIN/s: LNS2, Lipin/Ned1/Smp2 (InterPro:IPR013209), Lipin, N-terminal conserved region (InterPro:IPR007651); BEST Arabidopsis thaliana protein match is: phosphatidic acid phosphohydrolase 2 (TAIR:AT5G42870.1); Has 5210 Blast hits to 3195 proteins in 460 species: Archae - 22; Bacteria - 1897; Metazoa - 1353; Fungi - 717; Plants - 207; Viruses - 16; Other Eukaryotes - 998 (source: NCBI BLink).
    NP_974268.1
    • Lipin family protein; CONTAINS InterPro DOMAIN/s: LNS2, Lipin/Ned1/Smp2 (InterPro:IPR013209), Lipin, N-terminal conserved region (InterPro:IPR007651); BEST Arabidopsis thaliana protein match is: phosphatidic acid phosphohydrolase 2 (TAIR:AT5G42870.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2934592..2939511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202539.2 → NP_974268.1  Lipin family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974268.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D8L210, Q0WNF2, Q9SF47
      UniProtKB/TrEMBL
      A0A654F5I6
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 105
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:655 → 880
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:492 → 598
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    2. NM_111790.4 → NP_187567.1  Lipin family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187567.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D8L210, Q0WNF2, Q9SF47
      UniProtKB/TrEMBL
      A0A654F5I6
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 105
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:655 → 880
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:492 → 598
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    3. NM_001337827.1 → NP_001326239.1  Lipin family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D8L210, Q0WNF2, Q9SF47
      UniProtKB/TrEMBL
      A0A654F5I6
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 105
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:655 → 880
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:492 → 598
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    4. NM_001125132.1 → NP_001118604.1  Lipin family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118604.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D8L210, Q0WNF2, Q9SF47
      UniProtKB/TrEMBL
      A0A654F5I6
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 105
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:655 → 880
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:492 → 598
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SF47.1

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