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    slc8a4b solute carrier family 8 member 4b [ Danio rerio (zebrafish) ]

    Gene ID: 557499, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slc8a4bprovided by ZNC
    Official Full Name
    solute carrier family 8 member 4bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050809-103
    See related
    Ensembl:ENSDARG00000037145 AllianceGenome:ZFIN:ZDB-GENE-050809-103
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ncx4; ncx4b; slc8a1b
    Summary
    Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in calcium ion import across plasma membrane and sodium ion transmembrane transport. Predicted to act upstream of or within cell communication; metal ion transport; and transmembrane transport. Predicted to be located in plasma membrane. Predicted to be active in axon; postsynapse; and sarcolemma. Is expressed in brain; eye; and ovary. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See slc8a4b in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (60161045..60245613)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (59855747..59935985)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene heat shock protein 12B Neighboring gene chaperonin containing TCP1, subunit 7 (eta) Neighboring gene phospholipase C, beta 3 (phosphatidylinositol-specific) Neighboring gene uncharacterized LOC137496230 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14Bb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish mutant bumper shows a hyperproliferation of lens epithelial cells and fibre cell degeneration leading to functional blindness. Schonthaler HB, et al. Mech Dev, 2010 Apr. PMID 20117205
    2. Phylogeny of Na+/Ca2+ exchanger (NCX) genes from genomic data identifies new gene duplications and a new family member in fish species. Marshall CR, et al. Physiol Genomics, 2005 Apr 14. PMID 15741504
    3. Remodeling of the hyomandibular skeleton and facial nerve positioning during embryonic and postembryonic development of teleost fish. Iwasaki M, et al. Dev Biol, 2022 Sep. PMID 35750208
    4. Single-cell resolution of MET- and EMT-like programs in osteoblasts during zebrafish fin regeneration. Tang WJ, et al. iScience, 2022 Feb 18. PMID 35169687, Free PMC Article
    5. Expression and water calcium dependence of calcium transporter isoforms in zebrafish gill mitochondrion-rich cells. Liao BK, et al. BMC Genomics, 2007 Oct 4. PMID 17915033, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium:sodium antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium:sodium antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 8 member 4b
    Names
    sodium/calcium exchanger 4
    solute carrier family 8 (sodium/calcium exchanger), member 4b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123240.1 → NP_001116712.1  solute carrier family 8 member 4b precursor

      See identical proteins and their annotated locations for NP_001116712.1

      Status: PROVISIONAL

      Source sequence(s)
      EU559291
      UniProtKB/TrEMBL
      B2CZC7
      Conserved Domains (5) summary
      smart00237
      Location:533 → 622
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:8 → 925
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:751 → 916
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam03160
      Location:401 → 491
      Calx-beta; Calx-beta domain
      pfam16494
      Location:249 → 380
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      60161045..60245613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166536.5 → XP_005166593.1  solute carrier family 8 member 4b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BE09, F1QA32
      Related
      ENSDARP00000054006.4, ENSDART00000054007.7
      Conserved Domains (5) summary
      smart00237
      Location:533 → 622
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:8 → 925
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:751 → 916
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam03160
      Location:401 → 491
      Calx-beta; Calx-beta domain
      pfam16494
      Location:249 → 380
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
    Nucleotide Protein
    Heading Accession and Version

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