U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    mpped2 metallophosphoesterase domain containing 2b [ Danio rerio (zebrafish) ]

    Gene ID: 336959, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    mpped2provided by ZNC
    Official Full Name
    metallophosphoesterase domain containing 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8903
    See related
    Ensembl:ENSDARG00000034443 AllianceGenome:ZFIN:ZDB-GENE-030131-8903
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    brpl; cb1097; fk34e08; zgc:56667; wu:fk34e08
    Summary
    Predicted to enable hydrolase activity. Acts upstream of or within podocyte development. Is expressed in several structures, including immature eye; nervous system; neural keel; neural plate; and neural tube. Orthologous to human MPPED2 (metallophosphoesterase domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See mpped2 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (14694876..14739058)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (14598476..14642660)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene neuron navigator 2b Neighboring gene uncharacterized LOC137489336 Neighboring gene uncharacterized LOC137489337 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 24

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Phylogenetic analysis and developmental expression of brp-like genes in amphioxus and zebrafish. Lin Y, et al. Comp Biochem Physiol B Biochem Mol Biol, 2005 May. PMID 15820136
    2. Genome-wide association and functional follow-up reveals new loci for kidney function. Pattaro C, et al. PLoS Genet, 2012. PMID 22479191, Free PMC Article
    3. Systematic human/zebrafish comparative identification of cis-regulatory activity around vertebrate developmental transcription factor genes. Navratilova P, et al. Dev Biol, 2009 Mar 15. PMID 19073165
    4. Genome-wide analysis of facial skeletal regionalization in zebrafish. Askary A, et al. Development, 2017 Aug 15. PMID 28705894, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within podocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    metallophosphoesterase MPPED2
    Names
    metallophosphoesterase domain containing 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200042.2 → NP_956336.1  metallophosphoesterase MPPED2

      See identical proteins and their annotated locations for NP_956336.1

      Status: VALIDATED

      Source sequence(s)
      CR388067, CR407545
      UniProtKB/TrEMBL
      A0A2R8QPY9, F6NNC5, Q7ZUB6
      Related
      ENSDARP00000050477.5, ENSDART00000050478.6
      Conserved Domains (2) summary
      cd07379
      Location:59 → 271
      MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
      pfam00149
      Location:59 → 255
      Metallophos; Calcineurin-like phosphoesterase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      14694876..14739058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005174308.5 → XP_005174365.1  metallophosphoesterase MPPED2 isoform X1

      See identical proteins and their annotated locations for XP_005174365.1

      UniProtKB/TrEMBL
      A0A2R8QPY9, F6NNC5, Q7ZUB6
      Related
      ENSDARP00000144980.1, ENSDART00000188093.1
      Conserved Domains (2) summary
      cd07379
      Location:59 → 271
      MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
      pfam00149
      Location:59 → 255
      Metallophos; Calcineurin-like phosphoesterase

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395193.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      1..801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395369.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      431775..475156
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.