abcb8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: abcb8provided by ZNC
Official Full Name: ATP-binding cassette, sub-family B (MDR/TAP), member 8provided by ZNC
Primary source: ZFIN:ZDB-GENE-050410-6
See related: Ensembl:ENSDARG00000056672 AllianceGenome:ZFIN:ZDB-GENE-050410-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: MITOSUR; zgc:113037
Summary: Predicted to enable ATP binding activity and ATPase-coupled transmembrane transporter activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within potassium ion transport. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial ATP-gated potassium channel complex. Predicted to be active in membrane and mitochondrion. Is expressed in female organism. Orthologous to human ABCB8 (ATP binding cassette subfamily B member 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (33781485..33801631, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (33895310..33915456, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D1S3690 (e-PCR)
- UniSTS:474268

fc19h06.y1 (e-PCR)
- UniSTS:192960

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of mitochondrial ATP-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mitochondrial potassium channel ATP-binding subunit

Names: ATP-binding cassette sub-family B member 8, mitochondrial; mitochondrial sulfonylurea-receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017544.1 → NP_001017544.1 mitochondrial potassium channel ATP-binding subunit

See identical proteins and their annotated locations for NP_001017544.1

Status: PROVISIONAL

Source sequence(s)

BC092161

UniProtKB/Swiss-Prot

F1QTQ6, Q56A55

Related

ENSDARP00000073658.4, ENSDART00000079202.6

Conserved Domains (2) summary

cd03249
Location:470 → 708

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

cd18574
Location:149 → 443

ABC_6TM_ABCB8_like; Six-transmembrane helical domain (6-TMD) of ATP-binding cassette transporter subfamily B member 8, mitochondrial, and similar proteins