kif7 kinesin family member 7 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kif7provided by ZNC
Official Full Name: kinesin family member 7provided by ZNC
Primary source: ZFIN:ZDB-GENE-050307-1
See related: Ensembl:ENSDARG00000033099 AllianceGenome:ZFIN:ZDB-GENE-050307-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cos2; costal2
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within determination of left/right symmetry; negative regulation of smoothened signaling pathway; and photoreceptor cell outer segment organization. Located in cilium and cytoplasm. Part of Hedgehog signaling complex. Is expressed in head; myotome; neural tube; otic vesicle; and somite. Used to study idiopathic scoliosis. Human ortholog(s) of this gene implicated in acrocallosal syndrome; cleft lip; and hydrolethalus syndrome 2. Orthologous to human KIF7 (kinesin family member 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (14394517..14446536, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (14148882..14201101, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutations in KIF7 implicated in idiopathic scoliosis in humans and axial curvatures in zebrafish.
Title: Mutations in KIF7 implicated in idiopathic scoliosis in humans and axial curvatures in zebrafish.
both osm-3/kif17 and cos2/kif7 have comparable outer segment developmental delays, although through independent mechanisms.
Title: Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms.
results suggested that PPFIA1 functioned with PP2A to promote the dephosphorylation of Kif7, triggering Kif7 localization to the tips of primary cilia and promoting Gli transcriptional activity.
Title: The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling.
We show that Kif7 interacts with both Gli1 and Gli2a and suggest that it functions to sequester Gli proteins in the cytoplasm, in a manner analogous to the regulation of Ci by Cos2 in Drosophila
Title: Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo.
zebrafish Costal2 acts as an intracellular repressor of signal transduction
Title: A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule-based movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photoreceptor cell outer segment organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Hedgehog signaling complex	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kinesin-like protein kif7

Names: kinesin-like protein costal2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014816.1 → NP_001014816.1 kinesin-like protein kif7

See identical proteins and their annotated locations for NP_001014816.1

Status: PROVISIONAL

Source sequence(s)

AY954727

UniProtKB/Swiss-Prot

Q58G59

Conserved Domains (3) summary

smart00129
Location:15 → 354

KISc; Kinesin motor, catalytic domain. ATPase

cd01372
Location:14 → 348

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

pfam04012
Location:716 → 924

PspA_IM30; PspA/IM30 family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

14394517..14446536 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005166379.5 → XP_005166436.1 kinesin-like protein kif7 isoform X1

UniProtKB/TrEMBL

A0A8M2BDV5, F1QH25

Related

ENSDARP00000041576.5, ENSDART00000041577.8

Conserved Domains (3) summary

smart00129
Location:15 → 354

KISc; Kinesin motor, catalytic domain. ATPase

cd01372
Location:14 → 348

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

pfam04012
Location:734 → 924

PspA_IM30; PspA/IM30 family