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    nmt2 N-myristoyltransferase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 556483, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nmt2provided by ZNC
    Official Full Name
    N-myristoyltransferase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-717
    See related
    Ensembl:ENSDARG00000021808 AllianceGenome:ZFIN:ZDB-GENE-030131-717
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    NMT 2; fb40e03; wu:fb40e03
    Summary
    Predicted to enable glycylpeptide N-tetradecanoyltransferase activity and peptidyl-lysine N6-myristoyltransferase activity. Predicted to be involved in N-terminal peptidyl-glycine N-myristoylation and protein localization to membrane. Predicted to act upstream of or within N-terminal protein myristoylation. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol. Orthologous to human NMT2 (N-myristoyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nmt2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (28578352..28592494)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (28643729..28657871)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene integrin, alpha 8 Neighboring gene family with sequence similarity 171 member A1 Neighboring gene ribonuclease P/MRP 38 subunit Neighboring gene acyl-CoA binding domain containing 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of differential transcript profiles between mutual crossbred embryos of zebrafish (Danio rerio) and Chinese rare minnow (Gobiocypris rarus) by cDNA-AFLP. Liu J, et al. Theriogenology, 2008 Dec. PMID 18692889
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycylpeptide N-tetradecanoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycylpeptide N-tetradecanoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycylpeptide N-tetradecanoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptidyl-lysine N6-myristoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-glycine N-myristoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within N-terminal protein myristoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycylpeptide N-tetradecanoyltransferase 2
    NP_001186683.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199754.1 → NP_001186683.1  glycylpeptide N-tetradecanoyltransferase 2

      Status: VALIDATED

      Source sequence(s)
      BC115323, BX322614, EB929892
      UniProtKB/Swiss-Prot
      A7YT82, F1QBV9
      UniProtKB/TrEMBL
      H2ZRH9
      Related
      ENSDARP00000124979.1, ENSDART00000149306.2
      Conserved Domains (3) summary
      COG5092
      Location:114 → 492
      NMT1; N-myristoyl transferase [Lipid metabolism]
      pfam01233
      Location:134 → 289
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:305 → 480
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      28578352..28592494
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A7YT82.2 GenPept UniProtKB/Swiss-Prot:A7YT82

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