U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    gpm6bb glycoprotein M6Bb [ Danio rerio (zebrafish) ]

    Gene ID: 503756, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    gpm6bbprovided by ZNC
    Official Full Name
    glycoprotein M6Bbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030710-10
    See related
    Ensembl:ENSDARG00000001676 AllianceGenome:ZFIN:ZDB-GENE-030710-10
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gpb6bb; zgc:110793
    Summary
    Predicted to be a structural constituent of myelin sheath. Predicted to be involved in axon development and central nervous system myelination. Predicted to be located in membrane. Predicted to be active in myelin sheath and plasma membrane. Is expressed in nervous system. Orthologous to human GPM6B (glycoprotein M6B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See gpm6bb in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (54751568..54840197, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (55162055..55186588, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 2 Neighboring gene OFD1 centriole and centriolar satellite protein Neighboring gene glycine receptor, alpha 2 Neighboring gene FA complementation group B

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The myelin proteolipid DMα in fishes. Brösamle C. Neuron Glia Biol, 2010 May. PMID 19508742
    2. Characterization of myelination in the developing zebrafish. Brösamle C, et al. Glia, 2002 Jul. PMID 12112375
    3. Evolution of myelin proteolipid proteins: gene duplication in teleosts and expression pattern divergence. Schweitzer J, et al. Mol Cell Neurosci, 2006 Jan. PMID 16289898
    4. Individual knock out of glycine receptor alpha subunits identifies a specific requirement of glra1 for motor function in zebrafish. Samarut E, et al. PLoS One, 2019. PMID 31048868, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables structural constituent of myelin sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in central nervous system myelination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in myelin sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    glycoprotein M6Bb
    Names
    DMgamma2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013334.2 → NP_001013352.2  glycoprotein M6Bb isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL732610
      UniProtKB/TrEMBL
      Q5CZM4, Q8UUS8
      Related
      ENSDARP00000080128.5, ENSDART00000085693.7
      Conserved Domains (1) summary
      pfam01275
      Location:3 → 237
      Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

    2. NM_001362553.1 → NP_001349482.1  glycoprotein M6Bb isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL732610
      UniProtKB/TrEMBL
      Q5CZM4
      Conserved Domains (1) summary
      pfam01275
      Location:18 → 252
      Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

    3. NM_001362554.1 → NP_001349483.1  glycoprotein M6Bb isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has shorter and distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AL732610
      UniProtKB/TrEMBL
      Q5CZM4
      Related
      ENSDARP00000123414.2, ENSDART00000137214.3
      Conserved Domains (1) summary
      pfam01275
      Location:3 → 238
      Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      54751568..54840197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223371.1 → XP_068079472.1  glycoprotein M6Bb isoform X1

      UniProtKB/TrEMBL
      Q5CZM4
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools