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    fam49al family with sequence similarity 49 member A, like [ Danio rerio (zebrafish) ]

    Gene ID: 445212, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fam49alprovided by ZNC
    Official Full Name
    family with sequence similarity 49 member A, likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040801-125
    See related
    Ensembl:ENSDARG00000035907 AllianceGenome:ZFIN:ZDB-GENE-040801-125
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fam49a; fam49aa; zgc:100996
    Summary
    Predicted to enable small GTPase binding activity. Predicted to act upstream of or within regulation of actin filament polymerization. Predicted to be located in membrane. Is expressed in several structures, including central nervous system; hatching gland; neural tube; notochord; and segmental plate. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fam49al in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (30633453..30683697)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (31046145..31096384)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene hippocalcin like 4 Neighboring gene uncharacterized LOC110438138 Neighboring gene tRNA isopentenyltransferase 1 Neighboring gene MYCL proto-oncogene, bHLH transcription factor b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Ndrg1b and fam49ab modulate the PTEN pathway to control T-cell lymphopoiesis in the zebrafish. Li RA, et al. Blood, 2016 Dec 29. PMID 27827822
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC445212

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003606.3 → NP_001003606.1  uncharacterized protein LOC445212

      See identical proteins and their annotated locations for NP_001003606.1

      Status: VALIDATED

      Source sequence(s)
      BX950227, CU463182, EH584941
      UniProtKB/TrEMBL
      A0A8M2B6N7, Q6DC29
      Related
      ENSDARP00000052123.4, ENSDART00000052124.6
      Conserved Domains (1) summary
      pfam07159
      Location:17 → 319
      DUF1394; Protein of unknown function (DUF1394)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      30633453..30683697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159614.3 → XP_005159671.1  uncharacterized protein LOC445212 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IHE5, A0A8M6YUH1
      Conserved Domains (1) summary
      pfam07159
      Location:19 → 320
      DUF1394; Protein of unknown function (DUF1394)

    2. XM_017352223.2 → XP_017207712.1  uncharacterized protein LOC445212 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IHE5, A0A8M6YUH1
      Related
      ENSDARP00000144084.1, ENSDART00000175662.2
      Conserved Domains (1) summary
      pfam07159
      Location:19 → 320
      DUF1394; Protein of unknown function (DUF1394)

    3. XM_005159616.5 → XP_005159673.1  uncharacterized protein LOC445212 isoform X2

      See identical proteins and their annotated locations for XP_005159673.1

      UniProtKB/TrEMBL
      A0A8M2B6N7, Q6DC29
      Conserved Domains (1) summary
      pfam07159
      Location:17 → 319
      DUF1394; Protein of unknown function (DUF1394)
    Nucleotide Protein Strain
    Heading Accession and Version

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