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    hnrnph1 heterogeneous nuclear ribonucleoprotein H1 [ Danio rerio (zebrafish) ]

    Gene ID: 402984, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hnrnph1provided by ZNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein H1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1856
    See related
    Ensembl:ENSDARG00000040881 AllianceGenome:ZFIN:ZDB-GENE-040426-1856
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:77712
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in Sjogren's syndrome and syndromic X-linked intellectual developmental disorder bain type. Orthologous to several human genes including HNRNPH1 (heterogeneous nuclear ribonucleoprotein H1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See hnrnph1 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (6991187..7014891)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (6684452..6708154)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A/Ba Neighboring gene eukaryotic translation initiation factor 4E binding protein 3, like Neighboring gene RUN and FYVE domain containing 1 Neighboring gene heparin-binding EGF-like growth factor a Neighboring gene si:ch73-43g23.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Variants in HNRNPH1 are associated with high myopia in humans and ocular coloboma in zebrafish. Ouyang J, et al. Clin Genet, 2022 Nov. PMID 35989590
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Variants in HNRNPH1 are associated with high myopia in humans and ocular coloboma in zebrafish.
      Title: Variants in HNRNPH1 are associated with high myopia in humans and ocular coloboma in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC77712

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein H

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205684.1 → NP_991247.1  heterogeneous nuclear ribonucleoprotein H

      See identical proteins and their annotated locations for NP_991247.1

      Status: PROVISIONAL

      Source sequence(s)
      BC065439
      UniProtKB/TrEMBL
      A0A8M1PEX0, A0A8M2BGZ6, Q6P0V0
      Related
      ENSDARP00000059917.4, ENSDART00000059918.6
      Conserved Domains (4) summary
      COG0724
      Location:5 → 74
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12729
      Location:6 → 84
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:251 → 326
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cl17169
      Location:89 → 184
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      6991187..7014891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005169580.5 → XP_005169637.1  heterogeneous nuclear ribonucleoprotein H isoform X3

      UniProtKB/TrEMBL
      A0A8M2BGV0, A0A8M9QKJ1
      Conserved Domains (4) summary
      COG0724
      Location:5 → 74
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12729
      Location:6 → 84
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:251 → 326
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cl17169
      Location:89 → 184
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_005169579.5 → XP_005169636.1  heterogeneous nuclear ribonucleoprotein H isoform X1

      UniProtKB/TrEMBL
      A0A0R4IZE3, A0A8M2BGU6, A0A8M2BGZ6
      Related
      ENSDARP00000141886.1, ENSDART00000157635.2
      Conserved Domains (4) summary
      COG0724
      Location:5 → 74
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12729
      Location:6 → 84
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:251 → 326
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cl17169
      Location:89 → 184
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_068213180.1 → XP_068069281.1  heterogeneous nuclear ribonucleoprotein H isoform X2

      UniProtKB/TrEMBL
      A0A8M9QKJ1
    Nucleotide Protein
    Heading Accession and Version

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