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    klhl20 kelch-like family member 20 [ Danio rerio (zebrafish) ]

    Gene ID: 406274, updated on 4-Jan-2025

    Summary

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    Official Symbol
    klhl20provided by ZNC
    Official Full Name
    kelch-like family member 20provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1935
    See related
    Ensembl:ENSDARG00000038801 AllianceGenome:ZFIN:ZDB-GENE-040426-1935
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc33f09; zgc:66288; wu:fc33f09
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in telencephalon. Orthologous to human KLHL20 (kelch like family member 20). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See klhl20 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (34112115..34126879)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (34128882..34143661)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene patched 2 Neighboring gene eukaryotic translation initiation factor 2B, subunit 3 gamma Neighboring gene centromere protein L Neighboring gene aspartyl-tRNA synthetase 2, mitochondrial

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Active DNA demethylation at enhancers during the vertebrate phylotypic period. Bogdanović O, et al. Nat Genet, 2016 Apr. PMID 26928226, Free PMC Article
    2. Saltatory evolution of the ectodermal neural cortex gene family at the vertebrate origin. Feiner N, et al. Genome Biol Evol, 2013. PMID 23843192, Free PMC Article
    3. Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg during zebrafish development. Tallafuss A, et al. Gene Expr Patterns, 2006 Jun. PMID 16448862
    4. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 20
    Names
    kelch-like 20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213001.1 → NP_998166.1  kelch-like protein 20

      See identical proteins and their annotated locations for NP_998166.1

      Status: PROVISIONAL

      Source sequence(s)
      BC057505
      UniProtKB/TrEMBL
      Q6PFL3
      Related
      ENSDARP00000122821.1, ENSDART00000146624.3
      Conserved Domains (5) summary
      smart00612
      Location:319 → 364
      Kelch; Kelch domain
      PHA03098
      Location:53 → 490
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:259 → 303
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:41 → 144
      BTB; BTB/POZ domain
      cl06652
      Location:137 → 175
      BACK_like; BTB-And-C-terminal-Kelch (BACK) domain and similar domains

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      34112115..34126879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163492.5 → XP_005163549.1  kelch-like protein 20 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BAT8, E9QC58
      Related
      ENSDARP00000056665.4, ENSDART00000056666.6
      Conserved Domains (3) summary
      PHA03098
      Location:45 → 568
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:337 → 381
      Kelch; KELCH repeat [structural motif]
      cd18249
      Location:27 → 154
      BTB_POZ_KLHL20_KLEIP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20)
    Nucleotide Protein
    Heading Accession and Version

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