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    mmadhcb metabolism of cobalamin associated Db [ Danio rerio (zebrafish) ]

    Gene ID: 402886, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mmadhcbprovided by ZNC
    Official Full Name
    metabolism of cobalamin associated Dbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040704-50
    See related
    Ensembl:ENSDARG00000005870 AllianceGenome:ZFIN:ZDB-GENE-040704-50
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    My011; mmadhc; zgc:91819
    Summary
    Predicted to act upstream of or within cobalamin metabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblD. Orthologous to human MMADHC (metabolism of cobalamin associated D). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mmadhcb in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (23049504..23056240)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (23238635..23245371)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 27 subfamily A member 3 Neighboring gene Rho family GTPase 3b Neighboring gene LY6/PLAUR domain containing 6 Neighboring gene uncharacterized LOC137496471

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Many genes in fish have species-specific asymmetric rates of molecular evolution. Steinke D, et al. BMC Genomics, 2006 Feb 8. PMID 16466575, Free PMC Article
    2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cobalamin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    metabolism of cobalamin associated Db
    Names
    metabolism of cobalamin associated D
    methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205594.2 → NP_991157.2  metabolism of cobalamin associated Db

      Status: VALIDATED

      Source sequence(s)
      EH437230, EH459674, EH531169
      UniProtKB/TrEMBL
      A0A8M1PGE0, B0UYB6
      Related
      ENSDARP00000018012.7, ENSDART00000012478.9
      Conserved Domains (1) summary
      pfam10229
      Location:24 → 293
      DUF2246; Uncharacterized conserved protein (DUF2246)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      23049504..23056240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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