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    rpl3 ribosomal protein L3 [ Danio rerio (zebrafish) ]

    Gene ID: 322571, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rpl3provided by ZNC
    Official Full Name
    ribosomal protein L3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1291
    See related
    Ensembl:ENSDARG00000003599 AllianceGenome:ZFIN:ZDB-GENE-030131-1291
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fa99g02; wu:fb65e09; zgc:110350
    Summary
    Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Acts upstream of or within exocrine pancreas development. Predicted to be located in ribosome. Predicted to be part of cytosolic large ribosomal subunit. Is expressed in eye; liver; and pancreas. Used to study Shwachman-Diamond syndrome. Orthologous to human RPL3 (ribosomal protein L3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rpl3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (29867225..29871348, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (29736383..29740506, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490615 Neighboring gene calcium channel, voltage-dependent, gamma subunit 2a Neighboring gene small nucleolar RNA SNORA54 Neighboring gene small nucleolar RNA U83B Neighboring gene solute carrier family 25 member 39 Neighboring gene ribosomal protein L27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A Novel SLC5A5 Variant Reveals the Crucial Role of Kinesin Light Chain 2 in Thyroid Hormonogenesis. Martín M, et al. J Clin Endocrinol Metab, 2021 Jun 16. PMID 33912899, Free PMC Article
    2. Nuclear Organization during Hepatogenesis in Zebrafish Requires Uhrf1. Madakashira BP, et al. Genes (Basel), 2021 Jul 16. PMID 34356097, Free PMC Article
    3. Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development. Provost E, et al. Development, 2012 Sep. PMID 22872088, Free PMC Article
    4. Brain Proteome and Behavioural Analysis in Wild Type, BDNF(+/-) and BDNF(-/-) Adult Zebrafish (Danio rerio) Exposed to Two Different Temperatures. Maffioli E, et al. Int J Mol Sci, 2022 May 17. PMID 35628418, Free PMC Article
    5. Single-cell RNA-sequencing uncovers transcriptional states and fate decisions in haematopoiesis. Athanasiadis EI, et al. Nat Commun, 2017 Dec 11. PMID 29229905, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown or mutation of either rpl3 or pes resulted in impaired expansion of pancreatic progenitor cells.
      Title: Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC110350

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within exocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL3
    NP_001001590.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001590.1 → NP_001001590.1  large ribosomal subunit protein uL3

      See identical proteins and their annotated locations for NP_001001590.1

      Status: PROVISIONAL

      Source sequence(s)
      AY561514
      UniProtKB/TrEMBL
      A0A2R8Q924, Q5BJJ2, Q6Q418
      Related
      ENSDARP00000003700.7, ENSDART00000011251.10
      Conserved Domains (2) summary
      PTZ00103
      Location:1 → 400
      PTZ00103; 60S ribosomal protein L3; Provisional
      cl00324
      Location:3 → 375
      RplC; Ribosomal protein L3 [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      29867225..29871348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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