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    ptpn4b protein tyrosine phosphatase non-receptor type 4b [ Danio rerio (zebrafish) ]

    Gene ID: 407634, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ptpn4bprovided by ZNC
    Official Full Name
    protein tyrosine phosphatase non-receptor type 4bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6259
    See related
    Ensembl:ENSDARG00000000183 AllianceGenome:ZFIN:ZDB-GENE-030131-6259
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ptpn4a; fi40g11; wu:fi40g11; si:rp71-1n18.2
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in developmental process. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and cytoplasmic side of plasma membrane. Orthologous to human PTPN4 (protein tyrosine phosphatase non-receptor type 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ptpn4b in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (11779834..11847341, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (11750157..11817701, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene keratin 97 Neighboring gene keratin 96 Neighboring gene uncharacterized LOC137488912 Neighboring gene muscle RAS oncogene homolog b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration. Wu W, et al. Sci Rep, 2017 Aug 16. PMID 28814789, Free PMC Article
    2. Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish. van Eekelen M, et al. PLoS One, 2010 Sep 3. PMID 20838449, Free PMC Article
    3. Zebrafish as a model to study PTPs during development. Paardekooper Overman J, et al. Methods, 2014 Jan 15. PMID 23974070
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in developmental process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 4b
    Names
    protein tyrosine phosphatase MEG1
    protein tyrosine phosphatase MEG1b
    protein tyrosine phosphatase, non-receptor type 4, b
    protein tyrosine phosphatase, non-receptor type 4a
    NP_001037778.2
    XP_005174003.1
    XP_009294371.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044313.2 → NP_001037778.2  tyrosine-protein phosphatase non-receptor type 4b

      Status: PROVISIONAL

      Source sequence(s)
      AL645755
      UniProtKB/TrEMBL
      A0A8M1N938, Q1MTL1
      Related
      ENSDARP00000105661.2, ENSDART00000125423.4
      Conserved Domains (8) summary
      smart00194
      Location:662 → 910
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:30 → 222
      B41; Band 4.1 homologues
      cd00047
      Location:687 → 909
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:519 → 606
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:216 → 310
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      cd14473
      Location:122 → 214
      FERM_B-lobe; FERM domain B-lobe
      pfam08736
      Location:325 → 365
      FA; FERM adjacent (FA)
      pfam09379
      Location:33 → 97
      FERM_N; FERM N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      11779834..11847341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009296096.4 → XP_009294371.1  tyrosine-protein phosphatase non-receptor type 4b isoform X2

      UniProtKB/TrEMBL
      A0A8M3B5D0
      Conserved Domains (8) summary
      smart00194
      Location:661 → 914
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:30 → 222
      B41; Band 4.1 homologues
      cd00047
      Location:686 → 913
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:518 → 605
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:216 → 310
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      cd14473
      Location:122 → 214
      FERM_B-lobe; FERM domain B-lobe
      pfam08736
      Location:325 → 365
      FA; FERM adjacent (FA)
      pfam09379
      Location:33 → 97
      FERM_N; FERM N-terminal domain

    2. XM_005173946.5 → XP_005174003.1  tyrosine-protein phosphatase non-receptor type 4b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BLA0, F1QFY3
      Related
      ENSDARP00000000192.10, ENSDART00000000192.10
      Conserved Domains (8) summary
      smart00194
      Location:662 → 915
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:30 → 222
      B41; Band 4.1 homologues
      cd00047
      Location:687 → 914
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:519 → 606
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:216 → 310
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      cd14473
      Location:122 → 214
      FERM_B-lobe; FERM domain B-lobe
      pfam08736
      Location:325 → 365
      FA; FERM adjacent (FA)
      pfam09379
      Location:33 → 97
      FERM_N; FERM N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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