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    naxd NAD(P)HX dehydratase [ Danio rerio (zebrafish) ]

    Gene ID: 797867, updated on 27-Dec-2024

    Summary

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    Official Symbol
    naxdprovided by ZNC
    Official Full Name
    NAD(P)HX dehydrataseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080204-1
    See related
    Ensembl:ENSDARG00000077119 AllianceGenome:ZFIN:ZDB-GENE-080204-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    carkd; zgc:171429
    Summary
    Predicted to enable ATP-dependent NAD(P)H-hydrate dehydratase activity. Predicted to be involved in metabolite repair. Orthologous to human NAXD (NAD(P)HX dehydratase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See naxd in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (8894906..8923471)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (8919435..8945141)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene collagen, type IV, alpha 1 Neighboring gene collagen, type IV, alpha 2 Neighboring gene RAB20, member RAS oncogene family Neighboring gene ankyrin repeat domain 10b Neighboring gene ubiquitin conjugating enzyme E2 A, like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC171429

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent NAD(P)H-hydrate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent NAD(P)H-hydrate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydro-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in metabolite repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nicotinamide nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent (S)-NAD(P)H-hydrate dehydratase
    Names
    carbohydrate kinase domain containing
    NP_001103590.2
    NP_001315079.1
    XP_005167513.1
    XP_005167514.1
    XP_005167517.1
    XP_005167519.1
    XP_005167520.1
    XP_005167521.1
    XP_068079584.1
    XP_068079585.1
    XP_068079586.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110120.2 → NP_001103590.2  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX539345
      UniProtKB/TrEMBL
      A8KB11
      Related
      ENSDARP00000102965.4, ENSDART00000111214.4

    2. NM_001328150.1 → NP_001315079.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform 1

      Status: PROVISIONAL

      Source sequence(s)
      BX539345
      UniProtKB/TrEMBL
      A0A8M1P3L1, E7F490
      Related
      ENSDARP00000107908.3, ENSDART00000130208.3
      Conserved Domains (2) summary
      cd01171
      Location:347 → 615
      YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.
      pfam13837
      Location:11 → 94
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      8894906..8923471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223484.1 → XP_068079585.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X6

      UniProtKB/TrEMBL
      A8KB11

    2. XM_068223485.1 → XP_068079586.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X7

      UniProtKB/TrEMBL
      A8KB11

    3. XM_005167463.5 → XP_005167520.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X8

      UniProtKB/TrEMBL
      A0A8M2BEU7
      Conserved Domains (1) summary
      cd01171
      Location:58 → 326
      YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.

    4. XM_005167460.5 → XP_005167517.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X3

      UniProtKB/TrEMBL
      A0A8M2BET0, A0A8M2BFH6
      Conserved Domains (1) summary
      cd01171
      Location:202 → 470
      YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.

    5. XM_068223483.1 → XP_068079584.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X4

      UniProtKB/TrEMBL
      A0A8M2BET0
      Related
      ENSDARP00000148059.1, ENSDART00000179969.1

    6. XM_005167462.5 → XP_005167519.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X5

      UniProtKB/TrEMBL
      A0A8M2BET0, A0A8M2BEY3
      Conserved Domains (1) summary
      cd01171
      Location:192 → 460
      YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.

    7. XM_005167464.5 → XP_005167521.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X9

      See identical proteins and their annotated locations for XP_005167521.1

      UniProtKB/Swiss-Prot
      F1Q575
      Related
      ENSDARP00000123516.1, ENSDART00000147098.3
      Conserved Domains (1) summary
      cd01171
      Location:52 → 320
      YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.

    8. XM_005167456.5 → XP_005167513.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X1

      UniProtKB/TrEMBL
      A0A8M2BEU4
      Conserved Domains (2) summary
      cd01171
      Location:343 → 611
      YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.
      pfam13837
      Location:11 → 94
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    9. XM_005167457.5 → XP_005167514.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X2

      UniProtKB/TrEMBL
      A0A8M2BEW7
      Conserved Domains (2) summary
      cd01171
      Location:337 → 605
      YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.
      pfam13837
      Location:11 → 94
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1Q575.1 GenPept UniProtKB/Swiss-Prot:F1Q575

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