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    MFP2 multifunctional protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819870, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MFP2
    Official Full Name
    multifunctional protein 2
    Primary source
    TAIR:AT3G06860
    Locus tag
    AT3G06860
    See related
    Araport:AT3G06860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMFP2; F3E22.20; multifunctional protein 2; MULTIFUNCTIONAL PROTEIN 2
    Summary
    Encodes a multifunctional protein. Involved in peroxisomal fatty acid beta oxidation. Loss-of-function mutant lacks hydroxyacyl-CoA dehydrogenase activity and have reduced levels of long-chain enoyl-CoA hydratase activity. The mutant has fewer but larger peroxisomes.
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    Genomic context

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    See MFP2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    18
    Sequence:
    Chromosome: 3; NC_003074.8 (2161735..2166357)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Mov34/MPN/PAD-1 family protein Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily Neighboring gene uncharacterized protein Neighboring gene 2-oxoacid dehydrogenases acyltransferase family protein Neighboring gene vitellogenin-like protein Neighboring gene proline-rich family protein Neighboring gene Transducin/WD40 repeat-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis thaliana multifunctional protein gene (MFP2) of peroxisomal beta-oxidation is essential for seedling establishment. Rylott EL, et al. Plant J, 2006 Mar. PMID 16507084
    2. The multifunctional protein AtMFP2 is co-ordinately expressed with other genes of fatty acid beta-oxidation during seed germination in Arabidopsis thaliana (L.) Heynh. Eastmond PJ, et al. Biochem Soc Trans, 2000 Feb. PMID 10816107
    3. The multifunctional protein in peroxisomal beta-oxidation: structure and substrate specificity of the Arabidopsis thaliana protein MFP2. Arent S, et al. J Biol Chem, 2010 Jul 30. PMID 20463021, Free PMC Article
    4. A defect in beta-oxidation causes abnormal inflorescence development in Arabidopsis. Richmond TA, et al. Plant Cell, 1999 Oct. PMID 10521521, Free PMC Article
    5. Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms. Reumann S, et al. Plant Cell, 2007 Oct. PMID 17951448, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of structure and substrate specificity of the Arabidopsis thaliana protein MFP2
      Title: The multifunctional protein in peroxisomal beta-oxidation: structure and substrate specificity of the Arabidopsis thaliana protein MFP2.
    2. An exogenous supply of sucrose is required in mfp2 mutants for seedling establishment. Seed storage lipids are catabolized more slowly, long-chain acyl-CoA substrates accumulate, and there is an increase in peroxisome size in mfp2-1 mutants.
      Title: The Arabidopsis thaliana multifunctional protein gene (MFP2) of peroxisomal beta-oxidation is essential for seedling establishment.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_111566.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3-hydroxyacyl-CoA dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-hydroxyacyl-CoA dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-hydroxyacyl-CoA dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables 3-hydroxybutyryl-CoA epimerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables delta(3)-delta(2)-enoyl-CoA isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enoyl-CoA hydratase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid beta-oxidation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in peroxisome HDA PubMed 
    located_in peroxisome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plant-type cell wall HDA PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    multifunctional protein 2
    NP_187342.1
    • multifunctional protein 2 (MFP2); FUNCTIONS IN: enoyl-CoA hydratase activity, 3-hydroxyacyl-CoA dehydrogenase activity; INVOLVED IN: fatty acid beta-oxidation; LOCATED IN: nucleolus, cell wall, peroxisome; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Enoyl-CoA hydratase/isomerase, conserved site (InterPro:IPR018376), 3-hydroxyacyl-CoA dehydrogenase, conserved site (InterPro:IPR006180), 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro:IPR008927), Dehydrogenase, multihelical (InterPro:IPR013328), NAD(P)-binding domain (InterPro:IPR016040), 3-hydroxyacyl-CoA dehydrogenase, NAD binding (InterPro:IPR006176), Crotonase, core (InterPro:IPR001753), 3-hydroxyacyl-CoA dehydrogenase, C-terminal (InterPro:IPR006108); BEST Arabidopsis thaliana protein match is: Enoyl-CoA hydratase/isomerase family (TAIR:AT4G29010.1); Has 46309 Blast hits to 45272 proteins in 2450 species: Archae - 810; Bacteria - 29664; Metazoa - 2011; Fungi - 1039; Plants - 666; Viruses - 0; Other Eukaryotes - 12119 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2161735..2166357
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111566.4 → NP_187342.1  multifunctional protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187342.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZPI5
      UniProtKB/TrEMBL
      A0A5S9X9W7, A0A654F4T1
      Conserved Domains (1) summary
      PRK11154
      Location:11 → 711
      fadJ; fatty acid oxidation complex subunit alpha FadJ
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZPI5.1

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