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    smc4 structural maintenance of chromosomes 4 [ Danio rerio (zebrafish) ]

    Gene ID: 192332, updated on 9-Dec-2024

    Summary

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    Official Symbol
    smc4provided by ZNC
    Official Full Name
    structural maintenance of chromosomes 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020419-21
    See related
    Ensembl:ENSDARG00000038882 AllianceGenome:ZFIN:ZDB-GENE-020419-21
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb788; smc4l1; fb99b10; chunp6901; wu:fb99b10
    Summary
    Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in mitotic chromosome condensation. Predicted to act upstream of or within chromosome organization. Predicted to be located in chromosome and nucleus. Predicted to be part of condensin complex. Is expressed in several structures, including digestive system; nervous system; optic cup; otic vesicle; and pectoral fin. Orthologous to human SMC4 (structural maintenance of chromosomes 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See smc4 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (1534625..1573130)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (1569716..1608221)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene karyopherin alpha 4 (importin alpha 3) Neighboring gene chromosome 15 C3orf80 homolog Neighboring gene intraflagellar transport 80 homolog (Chlamydomonas) Neighboring gene microRNA 15c Neighboring gene microRNA 16a Neighboring gene tripartite motif containing 59 Neighboring gene nanor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The Zebrafish Meiotic Cohesin Complex Protein Smc1b Is Required for Key Events in Meiotic Prophase I. Islam KN, et al. Front Cell Dev Biol, 2021. PMID 34434933, Free PMC Article
    2. Expression of cohesin and condensin genes during zebrafish development supports a non-proliferative role for cohesin. Mönnich M, et al. Gene Expr Patterns, 2009 Dec. PMID 19723591
    3. Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development. Golling G, et al. Nat Genet, 2002 Jun. PMID 12006978
    4. Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. Smith LC, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2016 Sep. PMID 27156127, Free PMC Article
    5. Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Recher G, et al. Development, 2013 Dec. PMID 24198278

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of condensin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    structural maintenance of chromosomes protein 4
    Names
    MC4 structural maintenance of chromosomes 4-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173253.2 → NP_775360.2  structural maintenance of chromosomes protein 4

      Status: VALIDATED

      Source sequence(s)
      CR478286, EB930997, EB935660, EH586089, EH591853, EH603521, EH609354
      UniProtKB/TrEMBL
      A0A8N1TUC6, E7FGC2
      Related
      ENSDARP00000108838.2, ENSDART00000130413.4
      Conserved Domains (5) summary
      cd03274
      Location:81 → 240
      ABC_SMC4_euk; ATP-binding cassette domain of eukaryotic SMC4 proteins
      smart00968
      Location:612 → 726
      SMC_hinge; SMC proteins Flexible Hinge Domain
      pfam02463
      Location:82 → 1273
      SMC_N; RecF/RecN/SMC N terminal domain
      cl00459
      Location:866 → 1025
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl23887
      Location:274 → 435
      DUF4349; Domain of unknown function (DUF4349)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      1534625..1573130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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