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    lgi1a leucine-rich, glioma inactivated 1a [ Danio rerio (zebrafish) ]

    Gene ID: 323011, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lgi1aprovided by ZNC
    Official Full Name
    leucine-rich, glioma inactivated 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1731
    See related
    Ensembl:ENSDARG00000020493 AllianceGenome:ZFIN:ZDB-GENE-030131-1731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    LGIa; fb78h12; zgc:65886; wu:fb78h12
    Summary
    Acts upstream of or within brain development; locomotory behavior; and myelination. Predicted to be located in extracellular region and synapse. Predicted to be active in extracellular space. Is expressed in digestive system; heart; immature eye; nervous system; and skeletal muscle. Human ortholog(s) of this gene implicated in familial temporal lobe epilepsy 1. Orthologous to human LGI1 (leucine rich glioma inactivated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lgi1a in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (421231..430144)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (290940..299853)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487348 Neighboring gene trace amine-associated receptor 13c-like Neighboring gene trace amine-associated receptor 6-like Neighboring gene EGF containing fibulin extracellular matrix protein 1 Neighboring gene HEAT repeat containing 5B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A novel LGI1 missense mutation causes dysfunction in cortical neuronal migration and seizures. Liu F, et al. Brain Res, 2019 Oct 15. PMID 31301272
    2. Knockdown of zebrafish Lgi1a results in abnormal development, brain defects and a seizure-like behavioral phenotype. Teng Y, et al. Hum Mol Genet, 2010 Nov 15. PMID 20819949, Free PMC Article
    3. Loss of zebrafish lgi1b leads to hydrocephalus and sensitization to pentylenetetrazol induced seizure-like behavior. Teng Y, et al. PLoS One, 2011. PMID 22053218, Free PMC Article
    4. Using gene-history and expression analyses to assess the involvement of LGI genes in human disorders. Gu W, et al. Mol Biol Evol, 2005 Nov. PMID 16014869
    5. Functional phylogenetic analysis of LGI proteins identifies an interaction motif crucial for myelination. Kegel L, et al. Development, 2014 Apr. PMID 24715463

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of zebrafish Lgi1a results in abnormal development, brain defects and a seizure-like behavioral phenotype.
      Title: Knockdown of zebrafish Lgi1a results in abnormal development, brain defects and a seizure-like behavioral phenotype.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myelination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within myelination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich glioma-inactivated protein 1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199627.2 → NP_955921.2  leucine-rich glioma-inactivated protein 1a precursor

      Status: VALIDATED

      Source sequence(s)
      BC056753, CU570800
      UniProtKB/TrEMBL
      A8BBB1, F6NUE1, Q2HPG2, Q6P0D2, Q6PH13
      Related
      ENSDARP00000154846.1, ENSDART00000188212.1
      Conserved Domains (5) summary
      sd00031
      Location:79 → 102
      LRR_1; leucine-rich repeat [structural motif]
      pfam03736
      Location:303 → 349
      EPTP; EPTP domain
      pfam12799
      Location:101 → 141
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:101 → 161
      LRR_8; Leucine rich repeat
      cl15307
      Location:159 → 207
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      421231..430144
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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