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    thoc2 THO complex 2 [ Danio rerio (zebrafish) ]

    Gene ID: 368417, updated on 9-Dec-2024

    Summary

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    Official Symbol
    thoc2provided by ZNC
    Official Full Name
    THO complex 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030616-54
    See related
    Ensembl:ENSDARG00000037503 AllianceGenome:ZFIN:ZDB-GENE-030616-54
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    THO; Tho2; fb73e08; fd21d11; wu:fb73e08; wu:fd21d11; si:bz1o18.2
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to act upstream of or within mRNA processing. Predicted to be located in nucleus. Predicted to be part of THO complex part of transcription export complex. Human ortholog(s) of this gene implicated in X-linked intellectual disability-short stature-overweight syndrome. Orthologous to human THOC2 (THO complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See thoc2 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (12391871..12486627)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (12085857..12180613)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487569 Neighboring gene magnesium transporter 1 Neighboring gene glutamate receptor, ionotropic, AMPA 3b Neighboring gene uncharacterized LOC108192088

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos. Huang Y, et al. Genome Biol, 2023 Jan 19. PMID 36658633, Free PMC Article
    2. Identification of nodal signaling targets by array analysis of induced complex probes. Dickmeis T, et al. Dev Dyn, 2001 Dec. PMID 11748827
    3. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Baraban SC, et al. Nat Commun, 2013. PMID 24002024, Free PMC Article
    4. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article
    5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mRNA export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of THO complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of THO complex part of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    THO complex subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326547.1 → NP_001313476.1  THO complex subunit 2

      Status: VALIDATED

      Source sequence(s)
      BX470260, BX510993, BX511226, CT728579, DT063420, EB949114, EH443657
      UniProtKB/TrEMBL
      A0A8M1P3G8, F1R5B5
      Related
      ENSDARP00000099604.5, ENSDART00000115408.5

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      12391871..12486627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157134.5 → XP_005157191.1  THO complex subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B3X8, F1QXF4
      Related
      ENSDARP00000097404.3, ENSDART00000106626.5
      Conserved Domains (5) summary
      pfam11733
      Location:1442 → 1528
      NP1-WLL; Non-capsid protein NP1
      pfam08648
      Location:1442 → 1557
      DUF1777; Protein of unknown function (DUF1777)
      pfam11262
      Location:868 → 1167
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:562 → 636
      Thoc2; Transcription- and export-related complex subunit
      pfam16134
      Location:11 → 560
      THOC2_N; THO complex subunit 2 N-terminus

    RNA

    1. XR_011006083.1 RNA Sequence

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394897.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      1325..32438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001003847.1: Suppressed sequence

      Description
      NM_001003847.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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