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    f7 coagulation factor VII [ Danio rerio (zebrafish) ]

    Gene ID: 114423, updated on 9-Dec-2024

    Summary

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    Official Symbol
    f7provided by ZNC
    Official Full Name
    coagulation factor VIIprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010814-1
    See related
    Ensembl:ENSDARG00000034862 AllianceGenome:ZFIN:ZDB-GENE-010814-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb59f04; zgc:109870
    Summary
    Predicted to enable serine-type endopeptidase activity. Acts upstream of or within blood coagulation, fibrin clot formation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in blood plasma; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebral infarction; diabetes mellitus (multiple); factor VII deficiency; and obesity. Orthologous to human F7 (coagulation factor VII). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (119960..125246)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (119960..125246)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene glycoprotein A33 (transmembrane), paralog a Neighboring gene coagulation factor VII, like Neighboring gene coagulation factor VIIi Neighboring gene coagulation factor X

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Demonstration of the extrinsic coagulation pathway in teleostei: identification of zebrafish coagulation factor VII. Sheehan J, et al. Proc Natl Acad Sci U S A, 2001 Jul 17. PMID 11459993, Free PMC Article
    2. Genetic analysis of hemostasis and thrombosis using vascular occlusion. Gregory M, et al. Blood Cells Mol Dis, 2002 Nov-Dec. PMID 12547218
    3. Role of hepsin in factor VII activation in zebrafish. Khandekar G, et al. Blood Cells Mol Dis, 2014 Jan. PMID 23954211
    4. Comprehensive analysis of blood coagulation pathways in teleostei: evolution of coagulation factor genes and identification of zebrafish factor VIIi. Hanumanthaiah R, et al. Blood Cells Mol Dis, 2002 Jul-Aug. PMID 12482404
    5. Tetramethylpyrazine Protects Endothelial Injury and Antithrombosis via Antioxidant and Antiapoptosis in HUVECs and Zebrafish. Zhang Y, et al. Oxid Med Cell Longev, 2022. PMID 35898617, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within blood coagulation, fibrin clot formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    coagulation factor VII
    Names
    clotting factor
    NP_571894.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131819.2 → NP_571894.2  coagulation factor VII precursor

      See identical proteins and their annotated locations for NP_571894.2

      Status: PROVISIONAL

      Source sequence(s)
      BC095023
      UniProtKB/TrEMBL
      Q504H3
      Related
      ENSDARP00000018993.7, ENSDART00000013209.7
      Conserved Domains (5) summary
      smart00020
      Location:195 → 424
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:19 → 82
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:86 → 121
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:196 → 427
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:131 → 166
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      119960..125246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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