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    pcolcea procollagen C-endopeptidase enhancer a [ Danio rerio (zebrafish) ]

    Gene ID: 563867, updated on 9-Dec-2024

    Summary

    Official Symbol
    pcolceaprovided by ZNC
    Official Full Name
    procollagen C-endopeptidase enhancer aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041014-370
    See related
    Ensembl:ENSDARG00000056913 AllianceGenome:ZFIN:ZDB-GENE-041014-370
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    polce; fj16f06; zC237L4.5; wu:fj16f06; zgc:136636; si:ch211-237l4.5
    Summary
    Predicted to enable collagen binding activity and peptidase activator activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Orthologous to human PCOLCE (procollagen C-endopeptidase enhancer). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See pcolcea in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (22789070..22803740, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (22819881..22834288, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 88 a Neighboring gene si:ch211-237l4.6 Neighboring gene period circadian clock 1a Neighboring gene vesicle-associated membrane protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Clone Names

    • MGC136636

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables collagen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    procollagen C-endopeptidase enhancer a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030181.3NP_001025352.2  procollagen C-endopeptidase enhancer a precursor

      See identical proteins and their annotated locations for NP_001025352.2

      Status: VALIDATED

      Source sequence(s)
      AL807389
      UniProtKB/TrEMBL
      A0A8M1N7B6, Q1ECX8
      Related
      ENSDARP00000151294.1, ENSDART00000187968.1
      Conserved Domains (2) summary
      cd00041
      Location:157270
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd03576
      Location:355479
      NTR_PCOLCE; NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      22789070..22803740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)