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    nme9 NME/NM23 family member 9 [ Danio rerio (zebrafish) ]

    Gene ID: 100037319, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nme9provided by ZNC
    Official Full Name
    NME/NM23 family member 9provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070410-39
    See related
    Ensembl:ENSDARG00000098944 AllianceGenome:ZFIN:ZDB-GENE-070410-39
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    nme8; txndc3; zgc:162216
    Summary
    Predicted to enable nucleoside diphosphate kinase activity. Predicted to act upstream of or within CTP biosynthetic process; GTP biosynthetic process; and UTP biosynthetic process. Is expressed in male organism. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 6. Orthologous to several human genes including NME9 (NME/NM23 family member 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nme9 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (52394177..52446997)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (52872158..52906094)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496509 Neighboring gene bromodomain adjacent to zinc finger domain protein 2B Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1b Neighboring gene uncharacterized LOC137496510 Neighboring gene death-associated protein-like 1 homolog Neighboring gene death associated protein 1b Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 Neighboring gene membrane associated ring-CH-type finger 4b Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The NME gene family in zebrafish oogenesis and early development. Desvignes T, et al. Naunyn Schmiedebergs Arch Pharmacol, 2011 Oct. PMID 21394481
    2. The NM23 family in development. Bilitou A, et al. Mol Cell Biochem, 2009 Sep. PMID 19421718
    3. Stress-immune responses and DNA protection function of thioredoxin domain containing 12 in zebrafish (Danio rerio). Kulatunga DCM, et al. Fish Shellfish Immunol, 2019 Jan. PMID 30359749
    4. Nme protein family evolutionary history, a vertebrate perspective. Desvignes T, et al. BMC Evol Biol, 2009 Oct 23. PMID 19852809, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables nucleoside diphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within GTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within UTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thioredoxin domain-containing protein 6
    Names
    NM23-Z8
    NME/NM23 family member 8
    thioredoxin domain containing 3
    thioredoxin domain-containing protein 3 homolog
    txndc6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001089475.1 → NP_001082944.1  thioredoxin domain-containing protein 6

      See identical proteins and their annotated locations for NP_001082944.1

      Status: PROVISIONAL

      Source sequence(s)
      BC134923
      UniProtKB/TrEMBL
      A0A0R4ID35, A0A8M1NEA9, A4IG45
      Related
      ENSDARP00000130661.2, ENSDART00000163684.2
      Conserved Domains (5) summary
      smart00562
      Location:162 → 301
      NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
      cd02948
      Location:11 → 112
      TRX_NDPK; TRX domain, TRX and NDP-kinase (NDPK) fusion protein family; most members of this group are fusion proteins which contain one redox active TRX domain containing a CXXC motif and three NDPK domains, and are characterized as intermediate chains (ICs) of ...
      cd04416
      Location:161 → 296
      NDPk_TX; NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which ...
      cl00335
      Location:449 → 512
      NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
      pfam00334
      Location:314 → 450
      NDK; Nucleoside diphosphate kinase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      52394177..52446997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223263.1 → XP_068079364.1  thioredoxin domain-containing protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QJH0

    2. XM_021478587.2 → XP_021334262.1  thioredoxin domain-containing protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q4G2, A0A8M9QJH0
      Conserved Domains (2) summary
      cd02948
      Location:11 → 112
      TRX_NDPK; TRX domain, TRX and NDP-kinase (NDPK) fusion protein family; most members of this group are fusion proteins which contain one redox active TRX domain containing a CXXC motif and three NDPK domains, and are characterized as intermediate chains (ICs) of ...
      cd04416
      Location:449 → 578
      NDPk_TX; NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which ...

    3. XM_021478588.2 → XP_021334263.1  thioredoxin domain-containing protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q4G2, A0A8M9QJH0
      Conserved Domains (2) summary
      cd02948
      Location:11 → 112
      TRX_NDPK; TRX domain, TRX and NDP-kinase (NDPK) fusion protein family; most members of this group are fusion proteins which contain one redox active TRX domain containing a CXXC motif and three NDPK domains, and are characterized as intermediate chains (ICs) of ...
      cd04416
      Location:449 → 578
      NDPk_TX; NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which ...
    Nucleotide Protein Strain
    Heading Accession and Version

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