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    spegb striated muscle enriched protein kinase b [ Danio rerio (zebrafish) ]

    Gene ID: 563174, updated on 27-Dec-2024

    Summary

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    Official Symbol
    spegbprovided by ZNC
    Official Full Name
    striated muscle enriched protein kinase bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081104-517
    See related
    Ensembl:ENSDARG00000009567 AllianceGenome:ZFIN:ZDB-GENE-081104-517
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-195m20.1
    Summary
    Predicted to enable ATP binding activity and protein kinase activity. Predicted to be involved in muscle structure development. Predicted to act upstream of or within protein phosphorylation. Is expressed in head; post-vent region; and somite. Human ortholog(s) of this gene implicated in centronuclear myopathy 5. Orthologous to human SPEG (striated muscle enriched protein kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See spegb in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (41516993..41681053)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (41708219..41879266)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene nuclear envelope integral membrane protein 2 Neighboring gene major facilitator superfamily domain containing 6b Neighboring gene microRNA 732 Neighboring gene CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Neighboring gene microRNA 26a-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of a novel zebrafish model of SPEG-related centronuclear myopathy. Espinosa KG, et al. Dis Model Mech, 2022 May 1. PMID 35293586, Free PMC Article
    2. In vivo proteomic mapping through GFP-directed proximity-dependent biotin labelling in zebrafish. Xiong Z, et al. Elife, 2021 Feb 16. PMID 33591275, Free PMC Article
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in muscle structure development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    striated muscle enriched protein kinase b; striated muscle preferentially expressed protein kinase
    Names
    SPEG complex locus b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      41516993..41681053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009304895.4 → XP_009303170.2  striated muscle preferentially expressed protein kinase isoform X5

      UniProtKB/TrEMBL
      A0A8M3AW98, A0A8M9QG55
      Related
      ENSDARP00000112989.2, ENSDART00000138473.3
      Conserved Domains (5) summary
      cd00063
      Location:1138 → 1231
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1340 → 1429
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:1274 → 1336
      Ig; Immunoglobulin domain
      cl21453
      Location:3091 → 3347
      PKc_like; Protein Kinases, catalytic domain
      cl25751
      Location:23 → 482
      DUF4045; Domain of unknown function (DUF4045)

    2. XM_021479006.2 → XP_021334681.1  striated muscle preferentially expressed protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8M9QG49
      Conserved Domains (5) summary
      cd00063
      Location:1343 → 1436
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1545 → 1634
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:1479 → 1541
      Ig; Immunoglobulin domain
      cl21453
      Location:3296 → 3552
      PKc_like; Protein Kinases, catalytic domain
      cl25751
      Location:228 → 687
      DUF4045; Domain of unknown function (DUF4045)

    3. XM_021479007.2 → XP_021334682.1  striated muscle preferentially expressed protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A8M9PT16
      Conserved Domains (5) summary
      cd00063
      Location:1317 → 1410
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1519 → 1608
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:1453 → 1515
      Ig; Immunoglobulin domain
      cl21453
      Location:3270 → 3526
      PKc_like; Protein Kinases, catalytic domain
      cl25751
      Location:202 → 661
      DUF4045; Domain of unknown function (DUF4045)

    4. XM_021479008.2 → XP_021334683.1  striated muscle preferentially expressed protein kinase isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q582
      Conserved Domains (5) summary
      cd00063
      Location:1220 → 1313
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1422 → 1511
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:1356 → 1418
      Ig; Immunoglobulin domain
      cl21453
      Location:3173 → 3429
      PKc_like; Protein Kinases, catalytic domain
      cl25751
      Location:105 → 564
      DUF4045; Domain of unknown function (DUF4045)

    5. XM_068223672.1 → XP_068079773.1  striated muscle preferentially expressed protein kinase isoform X5

      UniProtKB/TrEMBL
      A0A8M3AW98, A0A8M9QG55

    6. XM_021479009.2 → XP_021334684.1  striated muscle preferentially expressed protein kinase isoform X4

      UniProtKB/TrEMBL
      A0A8M9QBJ0
      Conserved Domains (5) summary
      cd00063
      Location:1210 → 1303
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1412 → 1501
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:1346 → 1408
      Ig; Immunoglobulin domain
      cl21453
      Location:3163 → 3419
      PKc_like; Protein Kinases, catalytic domain
      cl25751
      Location:95 → 554
      DUF4045; Domain of unknown function (DUF4045)

    7. XM_021479010.2 → XP_021334685.1  striated muscle preferentially expressed protein kinase isoform X5

      UniProtKB/TrEMBL
      A0A8M3AW98, A0A8M9QG55
      Conserved Domains (5) summary
      cd00063
      Location:1138 → 1231
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1340 → 1429
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:1274 → 1336
      Ig; Immunoglobulin domain
      cl21453
      Location:3091 → 3347
      PKc_like; Protein Kinases, catalytic domain
      cl25751
      Location:23 → 482
      DUF4045; Domain of unknown function (DUF4045)
    Nucleotide Protein Strain
    Heading Accession and Version

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