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    eif2ak3 eukaryotic translation initiation factor 2-alpha kinase 3 [ Danio rerio (zebrafish) ]

    Gene ID: 559564, updated on 15-Dec-2024

    Summary

    Official Symbol
    eif2ak3provided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 2-alpha kinase 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050414-2
    See related
    Ensembl:ENSDARG00000062139 AllianceGenome:ZFIN:ZDB-GENE-050414-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    PEK; zgc:152949
    Summary
    Predicted to enable eukaryotic translation initiation factor 2alpha kinase activity. Acts upstream of or within response to endoplasmic reticulum stress and response to hypoxia. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; liver; and male organism. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Orthologous to human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See eif2ak3 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (13945216..14004550)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (13814162..13873558)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 4 member 11 Neighboring gene uncharacterized LOC137487374 Neighboring gene ribose 5-phosphate isomerase A (ribose 5-phosphate epimerase) Neighboring gene uncharacterized LOC101884819 Neighboring gene attractin Neighboring gene GDNF family receptor alpha 4a

    Genomic regions, transcripts, and products

    General gene information

    Clone Names

    • MGC152949

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables kinase activity  
    enables nucleotide binding  
    enables protein kinase activity  
    enables transferase activity  
    enables translation initiation factor activity  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in endoplasmic reticulum  
    located_in membrane  
    is_active_in nucleus  

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 2-alpha kinase 3
    Names
    PERK
    XP_005156642.2
    XP_021336441.1
    XP_068069115.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      13945216..14004550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213014.1 → XP_068069115.1  eukaryotic translation initiation factor 2-alpha kinase 3 isoform X2

    2. XM_021480766.2 → XP_021336441.1  eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QK34, B8JI14
      Related
      ENSDARP00000120826.1, ENSDART00000142997.2
      Conserved Domains (2) summary
      cd09768
      Location:100 → 437
      Luminal_EIF2AK3; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3
      cd14048
      Location:606 → 1063
      STKc_EIF2AK3_PERK; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394873.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      179275..234501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156585.5 → XP_005156642.2  eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B3B8
      Conserved Domains (2) summary
      cd09768
      Location:100 → 437
      Luminal_EIF2AK3; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3
      cd14048
      Location:606 → 1063
      STKc_EIF2AK3_PERK; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase

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