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    serpinf2a serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2a [ Danio rerio (zebrafish) ]

    Gene ID: 560308, updated on 9-Dec-2024

    Summary

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    Official Symbol
    serpinf2aprovided by ZNC
    Official Full Name
    serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060822-1
    See related
    Ensembl:ENSDARG00000076448 AllianceGenome:ZFIN:ZDB-GENE-060822-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    serpinf2; serpinf2l; wu:fd57d08
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be active in extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in COVID-19 and alpha-2-plasmin inhibitor deficiency. Orthologous to human SERPINF2 (serpin family F member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See serpinf2a in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (40092281..40104916)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (40068744..40081363)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 31 Neighboring gene solute carrier family 13 member 5a Neighboring gene serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 Neighboring gene solute carrier organic anion transporter family, member 2B1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transcriptomic characterization of adult zebrafish infected with Streptococcus agalactiae. Wu XM, et al. Fish Shellfish Immunol, 2019 Nov. PMID 31533079
    2. The first characterization of multidrug and toxin extrusion (MATE/SLC47) proteins in zebrafish (Danio rerio). Lončar J, et al. Sci Rep, 2016 Jun 30. PMID 27357367, Free PMC Article
    3. HNF factors form a network to regulate liver-enriched genes in zebrafish. Cheng W, et al. Dev Biol, 2006 Jun 15. PMID 16631158
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-2-antiplasmin
    Names
    serine (or cysteine) peptidase inhibitor, clade F, member 2
    serine (or cysteine) peptidase inhibitor, clade F, member 2a
    serpin peptidase inhibitor, clade F , member 2, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      40092281..40104916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_683705.8 → XP_688797.1  alpha-2-antiplasmin

      UniProtKB/TrEMBL
      A0A8N7T5R7, F6NQ58
      Related
      ENSDARP00000123643.1, ENSDART00000145150.3
      Conserved Domains (1) summary
      cl00137
      Location:54 → 388
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein Strain
    Heading Accession and Version

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