psmb1 proteasome 20S subunit beta 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: psmb1provided by ZNC
Official Full Name: proteasome 20S subunit beta 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040618-2
See related: Ensembl:ENSDARG00000009640 AllianceGenome:ZFIN:ZDB-GENE-040618-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fc51f06; zgc:103665
Summary: Acts upstream of or within brain development. Predicted to be part of proteasome core complex. Predicted to be active in cytoplasm and nucleus. Used to study intellectual disability and microcephaly. Orthologous to human PSMB1 (proteasome 20S subunit beta 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (1142725..1151345, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (1012434..1021054, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The proteasome subunit psmb1 is essential for craniofacial cartilage maturation and morphogenesis.
Title: The proteasome subunit psmb1 is essential for craniofacial cartilage maturation and morphogenesis.
Biallelic variants in PSMB1 encoding the proteasome subunit beta6 cause impairment of proteasome function, microcephaly, intellectual disability, developmental delay and short stature.
Title: Biallelic variants in PSMB1 encoding the proteasome subunit β6 cause impairment of proteasome function, microcephaly, intellectual disability, developmental delay and short stature.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proteasome subunit beta type-1

Names: proteasome (prosome, macropain) subunit, beta type, 1; proteasome beta-subunit C5; proteasome subunit beta 1

NP_001003889.1

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003889.1 → NP_001003889.1 proteasome subunit beta type-1

See identical proteins and their annotated locations for NP_001003889.1

Status: PROVISIONAL

Source sequence(s)

AY648806

UniProtKB/Swiss-Prot

B2GRC6, Q6DRF3

Related

ENSDARP00000011778.5, ENSDART00000007231.6

Conserved Domains (2) summary

COG0638
Location:22 → 237

PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]

cd03757
Location:26 → 237

proteasome_beta_type_1; proteasome beta type-1 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...