tal1 T-cell acute lymphocytic leukemia 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tal1provided by ZNC
Official Full Name: T-cell acute lymphocytic leukemia 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-501
See related: Ensembl:ENSDARG00000019930 AllianceGenome:ZFIN:ZDB-GENE-980526-501
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: scl; tal-1; SCL-beta; scl/tal1; SCL-alpha; zgc:85605
Summary: Enables sequence-specific DNA binding activity. Involved in circulatory system development and hemopoiesis. Acts upstream of or within several processes, including circulatory system development; hemopoiesis; and positive regulation of endothelial cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; hematopoietic cell; hematopoietic system; and mesoderm. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (16535585..16545329)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (16509315..16519059)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zygotic Vsx1 Plays a Key Role in Defining V2a Interneuron Sub-Lineage by Directly Repressing tal1 Transcription in Zebrafish.
Title: Zygotic Vsx1 Plays a Key Role in Defining V2a Interneuron Sub-Lineage by Directly Repressing tal1 Transcription in Zebrafish.
The latter data suggest that Stil play a role in retina cell proliferation through the Shh signal transduction pathway.
Title: Transcription of the SCL/TAL1 interrupting Locus (Stil) is required for cell proliferation in adult Zebrafish Retinas.
Tal1 has distinct roles in regulating the formation of endocardial intercellular junctions.
Title: tal1 Regulates the formation of intercellular junctions and the maintenance of identity in the endocardium.
Data suggest that a defined hemogenic endothelial population preset by scl-beta supports the deterministic emergence of HSCs, and unravel the cellular mechanisms by which scl isoforms regulate HSC development.
Title: Hemogenic endothelium specification and hematopoietic stem cell maintenance employ distinct Scl isoforms.
Our studies establish a new connection between RA and scl during development that may participate in stem cell self-renewal and hematopoietic differentiation
Title: Interaction of retinoic acid and scl controls primitive blood development.
Ets1-related protein plays a critical role in the initiation of definitive hematopoiesis by controlling the expression of 2 stem cell leukemia (scl) isoforms (scl-alpha and scl-beta) in angioblasts.
Title: Scl isoforms act downstream of etsrp to specify angioblasts and definitive hematopoietic stem cells.
the choice of endothelial versus myeloid fate depends on a combinatorial effect of etsrp, scl, and alk8 ge
Title: Interplay among Etsrp/ER71, Scl, and Alk8 signaling controls endothelial and myeloid cell formation.
These results demonstrate that scl is an important mediator of the ability of AML1-ETO to reprogram hematopoietic cell fate decisions, suggesting that scl may be an important contributor to AML1-ETO-associated leukemia.
Title: AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression.
While scl-alpha and -beta are redundant for the initiation of primitive hematopoiesis, these two isoforms exert distinct functions in the regulation of primitive erythroid differentiation and definitive hematopoietic stem cell specification.
Title: Distinct functions for different scl isoforms in zebrafish primitive and definitive hematopoiesis.
Scl/Tal1 is an indispensable component of the molecular hierarchy that controls endocardium morphogenesis.
Title: Early endocardial morphogenesis requires Scl/Tal1.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Markers

fd09h12.y1 (e-PCR)
- UniSTS:195088

scl (e-PCR), detects polymorphism
- UniSTS:187032

Z13794 (e-PCR)
- UniSTS:204711

scl (e-PCR), detects polymorphism
- UniSTS:205511

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in definitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocardium formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocardium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in erythrocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within erythrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hemangioblast cell differentiation	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within hemangioblast cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemangioblast cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within hemopoiesis	IGI Inferred from Genetic Interaction more info
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemopoiesis	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within lateral mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myeloid cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within nucleate erythrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of endothelial cell differentiation	IGI Inferred from Genetic Interaction more info
acts_upstream_of_or_within positive regulation of endothelial cell differentiation	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within primitive hemopoiesis	IDA Inferred from Direct Assay more info	PubMed
involved_in primitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thyroid gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculogenesis	IDA Inferred from Direct Assay more info
involved_in vasculogenesis	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: T-cell acute lymphocytic leukemia protein 1 homolog

Names: stem cell protein; stem-cell leukemia hematopoietic transcription factor; transcription factor; zSCL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.