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    surf1 SURF1 cytochrome c oxidase assembly factor [ Danio rerio (zebrafish) ]

    Gene ID: 557970, updated on 9-Dec-2024

    Summary

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    Official Symbol
    surf1provided by ZNC
    Official Full Name
    SURF1 cytochrome c oxidase assembly factorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041108-2
    See related
    Ensembl:ENSDARG00000003592 AllianceGenome:ZFIN:ZDB-GENE-041108-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:6898613; zgc:158646
    Summary
    Enables cytochrome-c oxidase activity. Acts upstream of or within several processes, including heart contraction; spinal cord motor neuron differentiation; and swimming behavior. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4K; Leigh disease; and mitochondrial complex IV deficiency nuclear type 1. Orthologous to human SURF1 (SURF1 cytochrome c oxidase assembly factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See surf1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (33281208..33283718)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (32681055..32683565)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene kynurenine aminotransferase 1 Neighboring gene surfeit 6 Neighboring gene small nucleolar RNA SNORD36 Neighboring gene small nucleolar RNA SNORD36 Neighboring gene ribosomal protein L7a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. N-acetylcysteine and cysteamine bitartrate prevent azide-induced neuromuscular decompensation by restoring glutathione balance in two novel surf1-/- zebrafish deletion models of Leigh syndrome. Haroon S, et al. Hum Mol Genet, 2023 Jun 5. PMID 36795052, Free PMC Article
    2. Novel Development of Magnetic Resonance Imaging to Quantify the Structural Anatomic Growth of Diverse Organs in Adult and Mutant Zebrafish. Sharma S, et al. Zebrafish, 2024 Feb. PMID 37603286,
    3. Early developmental pathology due to cytochrome c oxidase deficiency is revealed by a new zebrafish model. Baden KN, et al. J Biol Chem, 2007 Nov 30. PMID 17761683
    4. Robust activation of microhomology-mediated end joining for precision gene editing applications. Ata H, et al. PLoS Genet, 2018 Sep. PMID 30208061, Free PMC Article
    5. Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development. Hensley MR, et al. Sci Rep, 2016 Jun 13. PMID 27292017, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC158646

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cytochrome-c oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryonic organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial cytochrome c oxidase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spinal cord motor neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within swimming behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    surfeit locus protein 1
    Names
    surfeit 1
    NP_001073642.1
    XP_009299784.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080173.1 → NP_001073642.1  surfeit locus protein 1

      See identical proteins and their annotated locations for NP_001073642.1

      Status: PROVISIONAL

      Source sequence(s)
      BC129348
      UniProtKB/TrEMBL
      A1L248
      Related
      ENSDARP00000009060.7, ENSDART00000011337.8
      Conserved Domains (1) summary
      cd06662
      Location:83 → 298
      SURF1; SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      33281208..33283718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009301509.3 → XP_009299784.1  surfeit locus protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B2I7
      Conserved Domains (1) summary
      cd06662
      Location:1 → 179
      SURF1; SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring ...
    Nucleotide Protein Strain
    Heading Accession and Version

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