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    prkag2a protein kinase, AMP-activated, gamma 2 non-catalytic subunit a [ Danio rerio (zebrafish) ]

    Gene ID: 570761, updated on 4-Jan-2025

    Summary

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    Official Symbol
    prkag2aprovided by ZNC
    Official Full Name
    protein kinase, AMP-activated, gamma 2 non-catalytic subunit aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060929-160
    See related
    Ensembl:ENSDARG00000012625 AllianceGenome:ZFIN:ZDB-GENE-060929-160
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:153329
    Summary
    Predicted to enable kinase activity. Predicted to act upstream of or within fatty acid biosynthetic process and phosphorylation. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See prkag2a in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (28252520..28381430, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (28173361..28302253, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 4I1, like Neighboring gene uncharacterized LOC110438353 Neighboring gene SH3-domain GRB2-like endophilin B1a Neighboring gene negative regulator of reactive oxygen species

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish. Yang BY, et al. Am J Physiol Endocrinol Metab, 2018 Jul 1. PMID 29351486
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    5'-AMP-activated protein kinase subunit gamma-2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077179.2 → NP_001070647.2  5'-AMP-activated protein kinase subunit gamma-2a isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5'-terminal exon and a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      CU855779, FP017236
      UniProtKB/TrEMBL
      A0A8M1NBF3, F8W5P9
      Related
      ENSDARP00000125018.1, ENSDART00000148618.3

    2. NM_001328430.1 → NP_001315359.1  5'-AMP-activated protein kinase subunit gamma-2a isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CU694811, CU855779, FP017236
      UniProtKB/TrEMBL
      A0A8M1PAB4, A0A8M9PXM0, F1QJ49
      Related
      ENSDARP00000109004.3, ENSDART00000129174.4
      Conserved Domains (3) summary
      COG0517
      Location:300 → 416
      CBS; CBS domain [Signal transduction mechanisms]
      cd04618
      Location:143 → 272
      CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
      cd04641
      Location:300 → 418
      CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      28252520..28381430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009297511.4 → XP_009295786.1  5'-AMP-activated protein kinase subunit gamma-2a isoform X2

      UniProtKB/TrEMBL
      A0A8M3APB3, A0A8M9PLX0
      Conserved Domains (3) summary
      COG0517
      Location:407 → 523
      CBS; CBS domain [Signal transduction mechanisms]
      cd04618
      Location:250 → 379
      CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
      cd04641
      Location:407 → 525
      CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

    2. XM_021470213.2 → XP_021325888.1  5'-AMP-activated protein kinase subunit gamma-2a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PG44, A0A8M9PLX0
      Conserved Domains (3) summary
      cd04618
      Location:250 → 379
      CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
      cd04641
      Location:407 → 525
      CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
      cl25836
      Location:45 → 160
      Retinal; Retinal protein

    3. XM_068217101.1 → XP_068073202.1  5'-AMP-activated protein kinase subunit gamma-2a isoform X3

      UniProtKB/TrEMBL
      A0A8M9PLX0

    4. XM_068217102.1 → XP_068073203.1  5'-AMP-activated protein kinase subunit gamma-2a isoform X4

      UniProtKB/TrEMBL
      A0A8M9PXM0

    RNA

    1. XR_659834.4 RNA Sequence

    2. XR_011008556.1 RNA Sequence

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395180.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      2594..3044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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