slc25a1a solute carrier family 25 member 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc25a1aprovided by ZNC
Official Full Name: solute carrier family 25 member 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1172
See related: Ensembl:ENSDARG00000057110 AllianceGenome:ZFIN:ZDB-GENE-040426-1172
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: slc25a1; zgc:63578
Summary: Predicted to enable citrate secondary active transmembrane transporter activity. Involved in neuromuscular junction development. Acts upstream of or within regulation of mitochondrion organization. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in 2-hydroxyglutaric aciduria; combined D-2- and L-2-hydroxyglutaric aciduria; and congenital myasthenic syndrome. Orthologous to human SLC25A1 (solute carrier family 25 member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (23060391..23069323)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (23090939..23099871)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables citrate secondary active transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables citrate secondary active transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables tricarboxylic acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mitochondrial citrate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial citrate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuromuscular junction development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tricarboxylate transport protein A, mitochondrial

Names: cic; citrate transport protein A; solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1; solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1a; solute carrier family 25, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.