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    znrf2a zinc and ring finger 2a [ Danio rerio (zebrafish) ]

    Gene ID: 100124611, updated on 9-Dec-2024

    Summary

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    Official Symbol
    znrf2aprovided by ZNC
    Official Full Name
    zinc and ring finger 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070820-15
    See related
    Ensembl:ENSDARG00000077855 AllianceGenome:ZFIN:ZDB-GENE-070820-15
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:171663
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein K48-linked ubiquitination. Predicted to be located in lysosome. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane. Is expressed in telencephalon and yolk syncytial layer. Orthologous to human ZNRF2 (zinc and ring finger 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See znrf2a in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (1934481..1947403, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (1984627..1997628, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene si:ch211-149a19.3 Neighboring gene uncharacterized LOC137488428 Neighboring gene dentin sialophosphoprotein-like Neighboring gene maturin, neural progenitor differentiation regulator homolog (Xenopus) Neighboring gene SH3-domain binding protein 5a (BTK-associated)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transcriptional responses and mechanisms of copper nanoparticle toxicology on zebrafish embryos. Zhang Y, et al. J Hazard Mater, 2018 Feb 15. PMID 30216965
    2. Copper elevated embryonic hemoglobin through reactive oxygen species during zebrafish erythrogenesis. Zhou XY, et al. Aquat Toxicol, 2016 Jun. PMID 26991749
    3. Copper induce zebrafish retinal developmental defects via triggering stresses and apoptosis. Zhao G, et al. Cell Commun Signal, 2020 Mar 14. PMID 32169084, Free PMC Article
    4. Transcriptional profiles and copper stress responses in zebrafish cox17 mutants. Sun H, et al. Environ Pollut, 2020 Jan. PMID 31662245
    5. Atp7b deficiency induces zebrafish eye developmental defects. Wu Y, et al. Metallomics, 2023 May 2. PMID 37070960

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase znrf2-like
    NP_001096107.1
    XP_005170036.1
    XP_017207661.1
    XP_068071114.1
    XP_068071115.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102637.1 → NP_001096107.1  E3 ubiquitin-protein ligase znrf2-like

      See identical proteins and their annotated locations for NP_001096107.1

      Status: PROVISIONAL

      Source sequence(s)
      BC150372
      UniProtKB/TrEMBL
      A7E2J2
      Related
      ENSDARP00000125859.1, ENSDART00000134074.2
      Conserved Domains (1) summary
      pfam13639
      Location:136 → 176
      zf-RING_2; Ring finger domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      1934481..1947403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017352172.3 → XP_017207661.1  E3 ubiquitin-protein ligase znrf2-like isoform X2

      UniProtKB/TrEMBL
      A0A0R4IZG3, A0A8M2BHB6, B8JKY5
      Conserved Domains (1) summary
      pfam13639
      Location:136 → 176
      zf-RING_2; Ring finger domain

    2. XM_005169979.5 → XP_005170036.1  E3 ubiquitin-protein ligase znrf2-like isoform X2

      UniProtKB/TrEMBL
      A0A0R4IZG3, A0A8M2BHB6, B8JKY5
      Related
      ENSDARP00000104121.2, ENSDART00000113951.4
      Conserved Domains (1) summary
      pfam13639
      Location:136 → 176
      zf-RING_2; Ring finger domain

    3. XM_068215013.1 → XP_068071114.1  E3 ubiquitin-protein ligase znrf2-like isoform X1

      Related
      ENSDARP00000125764.1, ENSDART00000151293.3

    4. XM_068215014.1 → XP_068071115.1  E3 ubiquitin-protein ligase znrf2-like isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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